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Diffusion kurtosis imaging study of cerebral cortex microstructure damage in patients with normal tension glaucoma
LI Ting  QU Xiaoxia  WANG Qian  XIAN Junfang 

Cite this article as: Li T, Qu XX, Wang Q, et al. Diffusion kurtosis imaging study of cerebral cortex microstructure damage in patients with normal tension glaucoma[J]. Chin J Magn Reson Imaging, 2022, 13(11): 6-11. DOI:10.12015/issn.1674-8034.2022.11.002.


[Abstract] Objective Diffusion kurtosis imaging (DKI) was used to study the cerebral cortical microstructure alterations of normal tension glaucoma (NTG), so as to provide imaging evidence for further elucidating the mechanism of cerebral cortical alterations in NTG.Materials and Methods The DKI data of 37 NTG patients who were diagnosed in our hospital and 37 healthy control subjects recruited from November 2016 to May 2020 were analyzed. The fractional anisotropy (FA), mean kurtosis (MK), radial kurtosis (RK) and axial kurtosis (AK) of 44 brain regions of the two groups of subjects were extracted using the Human Connectome Project multimodal parcellation atlas. The differences between the two groups were compared using the student t-test. Afterwards, the correlations between the DKI parameters of abnormal brain areas and the mean defect of visual field in NTG patients were analyzed.Results In NTG patients, the FA values of bilateral insula and frontal opercular, temporoparietal occipital junction, superior parietal lobule, inferior parietal lobule, anterior cingulate gyrus and medial prefrontal lobe, left dorsolateral prefrontal lobe, right ventral stream of visual pathway, middle temporal complex (MT+) with neighboring visual areas, and early auditory cortex decreased (P＜0.05, FDR correction). The MK value of MT+ complex with neighboring visual areas decreased (P=0.0134, FDR correction). There was no significant difference between the RK values of NTG patients and those of the normal control subjects in the whole brain (P＞0.05, FDR correction). AK values decreased in bilateral MT+ complex with neighboring visual areas, insular lobe and frontal opercular, anterior cingulate gyrus and medial prefrontal lobe, left inferior parietal lobule, orbital gyrus and frontal pole, right ventral stream of visual pathway, and temporoparietal occipital junction (P<0.05, FDR correction). The FA values of bilateral temporoparietal occipital junction, right anterior cingulate gyrus and medial prefrontal lobe were positively correlated with the mean defect of visual field of both eyes. The FA values of left anterior cingulate gyrus and medial prefrontal lobe, and the ventral stream of right visual pathway were positively correlated with the mean defect of visual field of the left eye, and the FA values of right insula and frontal opercular were positively correlated with the mean defect of visual field of the right eye (P＜0.05).Conclusions DKI can detect the multiple microstructure damages in the cerebral cortex of NTG patients, including visual cortex, salience network, default network, dorsal attention network, temporoparietal occipital junction, early auditory cortex, orbital gyrus and frontal pole. FA value can reflect the correlation between brain microstructure damage and disease severity of patients, so it is a potential biological index.
[Keywords] normal tension glaucoma；brain；neurodegeneration；magnetic resonance imaging；diffusion kurtosis imaging；diffusion tensor imaging

LI Ting   QU Xiaoxia   WANG Qian   XIAN Junfang*  

Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

Xian JF, E-mail: cjr.xianjunfang@vip.163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81871340, 82071906, 81571649, 81701666, 81901719); Special Fund for Clinical Medicine Development of Beijing Hospital Administration (No. ZYLX201704); Special Fund for "Peak Climbing" Plan of Beijing Hospital Management Center (No. DFL20190203).
Received  2022-08-05
Accepted  2022-11-10
DOI: 10.12015/issn.1674-8034.2022.11.002
Cite this article as: Li T, Qu XX, Wang Q, et al. Diffusion kurtosis imaging study of cerebral cortex microstructure damage in patients with normal tension glaucoma[J]. Chin J Magn Reson Imaging, 2022, 13(11): 6-11. DOI:10.12015/issn.1674-8034.2022.11.002.

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