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The value of quantitative parameters on magnetization transfer imaging of lacrimal glands in distinguishing the clinical activity of thyroid-associated ophthalmopathy
JIANG Wenhao  HU Hao  CHEN Huanhuan  ZHOU Jiang  CHEN Lu  CHEN Wen  WU Qian  XU Xiaoquan  WU Feiyun 

Cite this article as: Jiang WH, Hu H, Chen HH, et al. The value of quantitative parameters on magnetization transfer imaging of lacrimal glands in distinguishing the clinical activity of thyroid-associated ophthalmopathy[J]. Chin J Magn Reson Imaging, 2022, 13(11): 17-21. DOI:10.12015/issn.1674-8034.2022.11.004.


[Abstract] Objective To investigate the value of quantitative parameters on magnetization transfer imaging (MTI) of lacrimal gland in distinguishing the clinical activity of thyroid-associated ophthalmopathy (TAO).Materials and Methods From September 2020 to January 2022, we prospectively recruited 49 TAO patients in the First Affiliated Hospital of Nanjing Medical University, and divided them into active groups (≥3 points, 29 patients) and inactive group (＜3 points, 20 patients) according to the Clinical Activity Score (CAS). All subjects underwent conventional MRI and coronal MTI scan of the orbit. Magnetization transmissibility ratio (MTR) of lacrimal glands and the signal intensity ratio (SIR) on fat suppression-T2WI between lacrimal glands and temporalis were measured, respectively. Mann-Whitney U test was applied to compare the differences of MRI quantitative parameters between two groups. The correlations between MRI parameters and CAS were evaluated using Spearman correlation analysis. Receiver operating characteristic curve analysis was used to assess the predictive value of each quantitative parameter in judging the clinical activity of TAO, and the area under the curves (AUC) were compared using the DeLong test.Results The MTRs of lacrimal glands in active group were significantly lower than those in inactive group (P＜0.001), while the SIRs of lacrimal glands in active group were significantly higher than those in inactive group (P＜0.001). MTR was mildly and negatively correlated with CAS (r=-0.427, P＜0.001), while SIR was weakly and positively correlated with CAS (r=0.252, P=0.012). The combination of MTR and SIR showed the optimal diagnostic performance in distinguishing the clinical activity of TAO (AUC=0.809, sensitivity 62.5%, specificity 93.1%), which was better than SIR alone, and the difference was statistically significant (Z=2.35, P=0.019).Conclusions The quantitative parameters on MTI of lacrimal glands are feasible in distinguishing clinical activity of TAO, which can be used as a supplement to conventional MRI sequences to improve the performance in evaluating the clinical activity of TAO.
[Keywords] thyroid-associated ophthalmopathy；clinical staging；lacrimal glands；magnetic resonance imaging；magnetization transfer imaging

JIANG Wenhao1   HU Hao1   CHEN Huanhuan2   ZHOU Jiang1   CHEN Lu1   CHEN Wen1   WU Qian1   XU Xiaoquan1   WU Feiyun1*  

1 Department of Radiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

2 Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

Wu FY, E-mail: wfy_njmu@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81801659).
Received  2022-07-07
Accepted  2022-11-10
DOI: 10.12015/issn.1674-8034.2022.11.004
Cite this article as: Jiang WH, Hu H, Chen HH, et al. The value of quantitative parameters on magnetization transfer imaging of lacrimal glands in distinguishing the clinical activity of thyroid-associated ophthalmopathy[J]. Chin J Magn Reson Imaging, 2022, 13(11): 17-21. DOI:10.12015/issn.1674-8034.2022.11.004.

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