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Research progress of brain magnetic resonance imaging in patients with primary open-angle glaucoma
YANG Bingbing  QU Xiaoxia  WANG Qian  LI Ting  XIAN Junfang 

Cite this article as: Yang BB, Qu XX, Wang Q, et al. Research progress of brain magnetic resonance imaging in patients with primary open-angle glaucoma[J]. Chin J Magn Reson Imaging, 2022, 13(11): 37-41. DOI:10.12015/issn.1674-8034.2022.11.007.


[Abstract] Glaucoma is the most frequent cause of irreversible blindness worldwide. As the most prevalent type of glaucoma, primary open-angle glaucoma (POAG) is facing challenges in pathogenesis, diagnosis, and management. In recent years, neuroimaging studies including multimodal MRI have shown that POAG is considered as a neurodegenerative disease. Alterations of brain structure, function, blood perfusion, and metabolism involving visual pathway and other brain regions were shown, which were correlated with the severity of the disease in POAG patients. In the future, multi-center prospective cohort studies with large sample sizes will be more needed, and multi-modal MRI data will be analyzed with machine learning and deep learning methods to investigate the relationship between changes in the central nervous system and their correlation with retinal changes and visual disorders, to provide a more explicit basis for early diagnosis and treatment. Therefore, MRI findings of the brain in patients with POAG and the potential role in the pathogenesis and diagnosis of POAG, as well as probable solutions to the unsolved problems, were systematically reviewed, aiming to provide a reference for the researchers in this field.
[Keywords] primary open-angle glaucoma；brain；magnetic resonance imaging；multimodality；advance

YANG Bingbing   QU Xiaoxia   WANG Qian   LI Ting   XIAN Junfang*  

Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China

Xian JF, E-mail: cjr.xianjunfang@vip.163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81571649, 81701666, 81871340, 81901719, 82071906); Special Fund for "Peak Climbing" Plan of Beijing Hospital Management Center (No. DFL20190203); Special Fund for Clinical Medicine Development of Beijing Hospital Administration (No. ZYLX201704).
Received  2022-08-08
Accepted  2022-11-10
DOI: 10.12015/issn.1674-8034.2022.11.007
Cite this article as: Yang BB, Qu XX, Wang Q, et al. Research progress of brain magnetic resonance imaging in patients with primary open-angle glaucoma[J]. Chin J Magn Reson Imaging, 2022, 13(11): 37-41. DOI:10.12015/issn.1674-8034.2022.11.007.

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