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The relationship of left ventricular myocardial fibrosis and left atrial function parameters of patients with hypertensive heart disease
XIA Rui  TAO Li  LIAO Jichun  ZHANG Zhiwei  YANG Haitao  LI Yongmei  LÜ Fajin  GAO Fabao 

Cite this article as: Xia R, Tao L, Liao JC, et al. The relationship of left ventricular myocardial fibrosis and left atrial function parameters of patients with hypertensive heart disease[J]. Chin J Magn Reson Imaging, 2022, 13(12): 20-25. DOI:10.12015/issn.1674-8034.2022.12.004.


[Abstract] Objective To investigate the characteristics of left ventricular myocardial fibrosis and the changes of left atrial and ventricular cardiac function in patients with hypertensive heart disease (HHD) by cardiac magnetic resonance (CMR), and to analyze the correlation between segmental left ventricular fibrosis and left atrial and ventricular function parameters.Materials and Methods Sixteen patients diagnosed with HHD cases (HHD group) in the Department of Cardiology of the First Affiliated Hospital of Chongqing Medical University from December 2021 to June 2022 and 16 data of healthy controls in the same period (control group) were retrospective analyzed. Left atrial ejection fraction (LAEF), left atrial end-diastolic volume (LAEDV), left atrial end-systolic volume (LAESV), left ventricular ejection fraction (LVEF), left ventricular end-diastolic volume (LVEDV), and left ventricular end-systolic volume (LVESV) were measured by cardiac cine sequences. T1 mapping sequence images were performed before and 15 min after the injection of Gd-DTPA. The commercial post-processing software was used to measure the left ventricular extracellular volume (ECV) and obtain the left ventricular myocardial T1 value (pre-T1) before contrast agent injection. The correlation between the values of ECV and pre-T1 and the functional parameters of the left atrium was analyzed in basal, midmyocardium and apex slices and ventricular septum, anterior myocardium, lateral myocardium and inferior myocardium segments.Results ECV and pre-T1 of HHD group were higher than control group (t=2.363, P=0.030; t=2.100, P=0.014). LAEF and LVEF were lower than control group (t=-3.932, P＜0.001; t=-4.251, P＜0.001), LAEDV, LAESV, LVEDV and LVESV were higher than control group (t=2.732, P=0.010; t=4.223, P＜0.001; t=2.898, P=0.010; t=3.208, P=0.006). There was a linear correlation between ECV of midmyocardial septum and LAEF in HHD group (r=0.663, P=0.005), and there was a linear correlation between pre-T1 of midmyocardial septum, basal anterior, basal lateral wall and LAEF (r=0.530, P=0.035; r=0.627, P=0.009; r=0.579, P=0.019).Conclusions We found the presence of diffuse myocardial fibrosis and the left atrial and ventricular function decreased in HHD patients, and there is a certain correlation between some segments of left ventricular fibrosis and left atrial function parameters in HHD patients, which suggesting that there was a causal relationship between the left ventricular myocardial fibrosis and the deterioration of left atrial function in HHD patients. This provides evidence for the interaction between left ventricular myocardial structure and left atrial function to promote the progression and poor prognosis of HHD.
[Keywords] hypertensive heart disease；left ventricular；myocardial fibrosis；left atrium；cardiac function parameters；cardiac magnetic resonance；magnetic resonance imaging

XIA Rui1   TAO Li1   LIAO Jichun1   ZHANG Zhiwei1   YANG Haitao1   LI Yongmei1   LÜ Fajin1*   GAO Fabao2  

1 Department of Radiology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China

2 Department of Radiology, West China Hospital of Sichuan University, Chengdu 610044

Lü FJ, E-mail: 986570736@qq.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81601546).
Received  2022-08-13
Accepted  2022-12-08
DOI: 10.12015/issn.1674-8034.2022.12.004
Cite this article as: Xia R, Tao L, Liao JC, et al. The relationship of left ventricular myocardial fibrosis and left atrial function parameters of patients with hypertensive heart disease[J]. Chin J Magn Reson Imaging, 2022, 13(12): 20-25. DOI:10.12015/issn.1674-8034.2022.12.004.

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