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Differential diagnostic value of T1 mapping and tissue tracking techniques in diseases associated with left ventricular hypertrophy
ZHANG Xinna  JIANG Yuqi  ZHAO Lingling  SHU Jingwei  YU Honglin  YANG Panpan  LIU Xiaoqin  ZHAO Ren  QIAN Yinfeng  YU Yongqiang  LI Xiaohu 

Cite this article as: Zhang XN, Jiang YQ, Zhao LL, et al. Differential diagnostic value of T1 mapping and tissue tracking techniques in diseases associated with left ventricular hypertrophy[J]. Chin J Magn Reson Imaging, 2022, 13(12): 32-37. DOI:10.12015/issn.1674-8034.2022.12.006.


[Abstract] Objective To study the value of T1 mapping by cardiac magnetic resonance (CMR) and tissue tracking (TT) in the differential diagnosis of cardiac amyloidosis (CA), hypertrophic cardiomyopathy (HCM) and hypertensive heart disease (HHD).Materials and Methods Twenty patients were recruited in HCM group, CA group and HHD group (combined case group), while 25 healthy volunteers were contained in healthy control (HC) group. Parameters of each group (HCM, CA, HHD and HC group) were retrospectively analyzed. One-way ANOVA and Kruskal-Wallis tests were used to compare native T1 values, relative apical sparing of strain (RAS), global and segmental longitudinal strain (LS), circumferential strain (CS), and radial strain (RS) between the four groups.Results The native T1 values in the CA group [(1473.05±16.70) ms] were significantly higher than those in the HCM [(1322.25±8.48) ms], HHD [(1289.05±9.18) ms] and HC groups [(1100.20±8.42) ms], and the native T1 values in the HCM group were higher than those in the HHD group, and the differences were statistically significant (P＜0.05). Global and segmental strains were lower in the case group than in the HC group, with statistically significant differences (P＜0.05). The CA relative apical radial strain (RASRS) ratio was 0.77±0.05 and the relative apical longitudinal strain (RASLS) ratio was 0.93±0.04. In the differential diagnosis of CA and HCM, the area under the curve (AUC) of native T1 value, basal radial strain (BRS), basal longitudinal strain (BLS), RASRS and RASLS were 0.95, 0.97, 0.92, 0.84 and 0.82 (P＜0.05). In the differential diagnosis of CA and HHD, the AUC of native T1, BRS, BLS, RASRS and RASLS were 0.97, 0. 74, 0.79, 0.73 and 0.80, respectively (P＜0.05). In the differential diagnosis of HCM and HHD, the AUC of native T1 and global longitudinal strain (GLS) were 0.74 and 0.69, respectively, and combining these two parameters resulted in a combined diagnostic index with an AUC of 0.81.Conclusions Significantly higher native T1 values and preserved relative apical strain can effectively discriminate CA from HCM and HHD, with BRS having the highest diagnostic efficacy in CA and HCM and native T1 in CA and HHD; native T1 values combined with GLS can help further improve the differential diagnostic efficacy in HCM and HHD. Based on the native T1 values of myocardial histological imaging parameters and myocardial strain parameters GLS and BRS measured by CMR can effectively identify HCM, CA and HHD, which can provide new ideas for the diagnosis of myocardial thickening disease etiology and treatment decisions.
[Keywords] hypertrophic cardiomyopathy；cardiac amyloidosis；hypertensive heart disease；cardiac magnetic resonance；magnetic resonance imaging；T1 mapping；tissue tracking；differential diagnosis

ZHANG Xinna1   JIANG Yuqi2   ZHAO Lingling2   SHU Jingwei1   YU Honglin1   YANG Panpan2   LIU Xiaoqin1   ZHAO Ren3   QIAN Yinfeng1   YU Yongqiang1   LI Xiaohu1*  

1 Department of Radiology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China

2 Department of Radiology, Fuyang Hospital, Anhui Medical University, Fuyang 236000, China

3 Department of Cardiovascular Medicine, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China

Li XH, E-mail: lixiaohu@ahmu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 82071897).
Received  2022-08-22
Accepted  2022-11-29
DOI: 10.12015/issn.1674-8034.2022.12.006
Cite this article as: Zhang XN, Jiang YQ, Zhao LL, et al. Differential diagnostic value of T1 mapping and tissue tracking techniques in diseases associated with left ventricular hypertrophy[J]. Chin J Magn Reson Imaging, 2022, 13(12): 32-37. DOI:10.12015/issn.1674-8034.2022.12.006.

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