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The value of MR endogenous contrast T1ρ technique in the detection of myocardial fibrosis in hypertrophic cardiomyopathy
WANG Keyan  ZHENG Jie  ZHANG Yong  HUANG Huiyu  ZHANG Wenbo  LI Shuman  JIN Hongrui  JIN Yanan  CHENG Jingliang 

Cite this article as: Wang KY, Zheng J, Zhang Y, et al. The value of MR endogenous contrast T1ρ technique in the detection of myocardial fibrosis in hypertrophic cardiomyopathy[J]. Chin J Magn Reson Imaging, 2022, 13(12): 51-57. DOI:10.12015/issn.1674-8034.2022.12.009.


[Abstract] Objective To investigate cardiac magnetic resonance (CMR) endogenous longitudinal relaxation time (T1ρ) in the diagnosis of myocardial fibrosis in patients with hypertrophic cardiomyopathy (HCM).Materials and Methods Sixty adult HCM patients and 20 age and sex matched healthy volunteers were prospectively included. All subjects received T1 mapping and T1ρ. According to whether the ventricular wall segments were hypertrophic, HCM was further divided into HCM ventricular wall normal thickness group (HCM-N) and HCM ventricular wall hypertrophic thickness (HCM-H) group. The initial T1 mapping, ECV and T1ρ were measured. The differences among healthy control group, HCM-N and HCM-H groups were analyzed and compared by one-way ANOVA. The consistency between extracellular volume fraction (ECV) and T1ρ were analyzed by Pearson. In addition, ECV as the reference, the value of T1ρ in the detection of myocardial fibrosis in HCM were analyzed.Results ECV gradually increased from control group to HCM-N group and to HCM-H group [Control (27.4±2.8) % vs. HCM-N (31.5±4.8) % vs. HCM-H (37.2±7.2) %; F=64.219, P＜0.001]. T1ρ mapping has the same trend as ECV [Control (38.4±1.5) ms vs. HCM-N (41.6±5.1) ms vs. HCM-H (47.4±7.9) ms; F=81.399, P＜0.001]. There were significant differences in ECV, T1ρ mapping between control group and HCM-N group, control group and HCM-H group, HCM-N group and HCM-H group (P＜0.001). There was significant difference in native T1 among control group, HCM-N group and HCM-H group [Control (1270.1±92.0) ms vs. HCM-N (1292.4±127.0) ms vs. HCM-H (1338.2±103.3) ms; F=9.921, P＜0.001]. There was no statistical difference in native T1 mapping between HCM-N and control group, but there were significant differences between HCM-N group and HCM-H group, and between HCM-H and control group. The consistency between ECV and T1ρ is 0.734.Conclusions CMR endogenous T1ρ could sensitively identify myocardial fibrosis in HCM patients,, and has potential clinical value in evaluating myocardial fibrosis.
[Keywords] hypertrophic cardiomyopathy；myocardial fibrosis；wall thickness, extracellular volume fraction；cardiac magnetic resonance；magnetic resonance imaging；endogenous contrast；T1ρ mapping；T1 mapping

WANG Keyan1   ZHENG Jie2   ZHANG Yong1   HUANG Huiyu1   ZHANG Wenbo1   LI Shuman1   JIN Hongrui1   JIN Yanan1   CHENG Jingliang1*  

1 Department of MRI, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China

2 Mallinckrodt Institute of Radiology, Washington University in St. Louis, St. Louis 63110, USA

Cheng JL, E-mail: fccchengjl@zzu.edu.cn

Conflicts of interest   None.

Received  2022-08-10
Accepted  2022-12-05
DOI: 10.12015/issn.1674-8034.2022.12.009
Cite this article as: Wang KY, Zheng J, Zhang Y, et al. The value of MR endogenous contrast T1ρ technique in the detection of myocardial fibrosis in hypertrophic cardiomyopathy[J]. Chin J Magn Reson Imaging, 2022, 13(12): 51-57. DOI:10.12015/issn.1674-8034.2022.12.009.

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