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• Clinical Article •
Altered characteristics of brain gray matter volume and structural covariance network in maintenance hemodialysis patients without neuropsychological disorder
ZHANG Die  CHEN Yingying  SHEN Jing  XIE Qing  JING Li  LIN Lin  DU Lina  WU Jianlin 

Cite this article as: Zhang D, Chen YY, Shen J, et al. Altered characteristics of brain gray matter volume and structural covariance network in maintenance hemodialysis patients without neuropsychological disorder[J]. Chin J Magn Reson Imaging, 2022, 13(12): 64-68, 80. DOI:10.12015/issn.1674-8034.2022.12.011.


[Abstract] Objective To explore changes characteristics in the gray matter volume (GMV) and structural covariant network (SCN) in maintenance hemodialysis (MHD) patients without neuropsychological disorder.Materials and Methods The 3D-T1 structural images of 23 MHD patients without neuropsychological disorder and 23 healthy controls (HC) were collected. The GMV of each participant was extracted from T1 structural images, and then the SCN based on group level was calculated according to the GMV of each participant. The group differences in the GMV and SCN related parameters were compared.Results Compared with HC, the patient group showed a significantly lower GMV in the right amygdala (P＜0.05, family wise error corrected). This lower GMV in patient group has no significant correlation with scores of cognition, anxiety, and depression. Two parameters at global level including the clustering coefficient (P=0.011) and local efficiency (P=0.003) were significantly higher in the patient group than in HC. To targeted attacks, when removing several specific nodes, the relative sizes of SCN in patient group was significantly higher than that of HC (all P＜0.05).Conclusions The combination of VBM and SCN analysis revealed the characteristics of reorganization of brain gray matter structure in MHD patients without neuropsychological disorder, and provide a novel perspective for understanding the mechanism of early brain damage in MHD patients.
[Keywords] end-stage renal disease；maintenance hemodialysis；gray matter volume；structural covariant network；brain structure；brain impairment；magnetic resonance imaging

ZHANG Die1, 2   CHEN Yingying1, 3   SHEN Jing1   XIE Qing1   JING Li1   LIN Lin1   DU Lina1   WU Jianlin1*  

1 Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, Dalian 116001, China

2 Department of Radiology, Shenzhen Third People's Hospital, Shenzhen 518000, China

3 Department of Radiology, Cancer Hospital & Shenzhen Hospital, Shenzhen 518116, China

Wu JL, E-mail: cjr.wujianlin@vip.163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Dalian Science and Technology Innovation Fund (No. 2021JJ12SN38).
Received  2022-08-11
Accepted  2022-11-09
DOI: 10.12015/issn.1674-8034.2022.12.011
Cite this article as: Zhang D, Chen YY, Shen J, et al. Altered characteristics of brain gray matter volume and structural covariance network in maintenance hemodialysis patients without neuropsychological disorder[J]. Chin J Magn Reson Imaging, 2022, 13(12): 64-68, 80. DOI:10.12015/issn.1674-8034.2022.12.011.

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