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• Original Article •
Quantitative assessment of arterial wall by magnetic resonance 3D DANTE CUBE sequence: An experimental study compared with pathology
ZHAO Haiyan  CHEN Yukun  CHEN Luguang  JIANG Hui  CHEN Shiyue  LI Shuai  PENG Wenjia  LU Jianping 

Cite this article as: Zhao HY, Chen YK, Chen LG, et al. Quantitative assessment of arterial wall by magnetic resonance 3D DANTE CUBE sequence: An experimental study compared with pathology[J]. Chin J Magn Reson Imaging, 2022, 13(12): 111-116, 123. DOI:10.12015/issn.1674-8034.2022.12.019.


[Abstract] Objective To quantitatively evaluate the consistency of arterial wall imaging and pathological results based on DANTE prepulse 3D CUBE magnetic resonance sequence.Materials and Methods Twelve New Zealand white rabbits were fed high-fat diet plus abdominal aortic strain surgery to establish atherosclerosis model, and 8 rabbits were fed ordinary diet as control group. The abdominal aorta was scanned with coronal black-blood DANTE CUBE T1WI and T2WI sequences using 3.0 T MRI system, followed by pathological HE staining. The MRI images were reconstructed in the horizontal axis, and lumen area (LA) and total area (TA) were measured in MRI and pathological images. The wall area (WA) was calculated, WA=TA-LA, and the normalized wall index (NWI) was calculated, NWI=WA/TA. The NWI of T1WI and T2WI are denoted by NWIT1 and NWIT2, respectively. The inner edge and outer edge of the adventitial of the vessel wall were delineated according to the pathological images, and the corresponding NWI were denoted by NWIP1 and NWIP2, respectively. The differences of MR imaging and pathological quantitative indexes between the experimental group and the control group were compared, and the NWI consistency between MRI sequences and between MRI and pathology were evaluated by intraclass correlation coefficient (ICC) and Bland-Altman plots.Results Finally, 19 rabbits (1 died before MRI examination in the experimental group) were included in the statistics. Compared with the control group, the LA of the experimental group was significantly smaller (T1WI, P=0.033; T2WI, P＜0.0001) and NWI were significantly larger (T1WI, P＜0.0001; T2WI, P＜0.0001). The overall consistency analysis showed that the consistency between NWIT1 and NWIT2 was better (ICC=0.7552), followed by the consistency between NWIT1 or NWIT2 and NWIP1 (ICC=0.438; ICC=0.444), NWIT1 or NWIT2 had the worst agreement with NWIP2 (ICC=0.285; ICC=0.292). The consistency analysis of the experimental group was similar to the above results. In the control group, the agreement between NWIT1 and NWIT2 was acceptable (ICC=0.6304), but the agreement between NWIT1 or NWIT2 and NWIP1 was poor (ICC=-0.1917; ICC=-0.05949), the consistency of NWIT1 or NWIT2 with NWIP2 was also poor (ICC=-0.1989; ICC=-0.1441).Conclusions The T1WI and T2WI of 3D DANTE CUBE can quantitatively distinguish the wall of atherosclerotic lesions from the normal wall of abdominal aorta in rabbits, and the consistency between the two commonly used weighted sequences is good. According to the consistency analysis between the NWI and pathology, the NWI measured by DANTE CUBE sequence is relatively close to the measurement results of the inner edge of the adventitia in pathological images, but the consistency is poor in general, especially in the comparison of normal vessels with thin vessel walls.
[Keywords] magnetic resonance imaging；vessel wall；atherosclerosis；rabbit；plaque；black blood imaging；delay alternating with nutation for tailored excitation

ZHAO Haiyan1   CHEN Yukun1   CHEN Luguang1   JIANG Hui2   CHEN Shiyue1   LI Shuai1   PENG Wenjia1*   LU Jianping1  

1 Department of Radiology, the First Affiliated Hospital of PLA Naval Medical University, Shanghai 200433, China

2 Department of Pathology, the First Affiliated Hospital of PLA Naval Medical University, Shanghai 200433, China

Peng WJ, E-mail: cindywpj@aliyun.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Natural Science Foundation of Shanghai (No. 22ZR1478100, 20ZR1456300); Medical Innovation Research Special Project of Shanghai Science and Technology Commission (No. 22Y11911200).
Received  2022-08-25
Accepted  2022-11-29
DOI: 10.12015/issn.1674-8034.2022.12.019
Cite this article as: Zhao HY, Chen YK, Chen LG, et al. Quantitative assessment of arterial wall by magnetic resonance 3D DANTE CUBE sequence: An experimental study compared with pathology[J]. Chin J Magn Reson Imaging, 2022, 13(12): 111-116, 123. DOI:10.12015/issn.1674-8034.2022.12.019.

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