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Cerebral perfusion in Parkinson's disease with depression: An arterial spin labeling MRI study
LI Xinyang  TIAN Yaotian  WANG Xiaonan  SU Wen  LI Shuhua  MA Xinxin  LI Chunmei  CHEN Min 

Cite this article as: LI X Y, TIAN Y T, WANG X N, et al. Cerebral perfusion in Parkinson’s disease with depression: An arterial spin labeling MRI study[J]. Chin J Magn Reson Imaging, 2023, 14(1): 6-12. DOI:10.12015/issn.1674-8034.2023.01.002.


[Abstract] Objective To explore the cerebral perfusion alteration in Parkinson's disease (PD) with depression and to investigate the associations of these alteration with depression.Materials and Methods A total of 34 PD patients [19 Parkinson's disease without depression (PD-n) patients, 15 Parkinson's disease with depression (PD-d) patients] and 30 sex-age matched normal controls (NC) were enrolled from September 2021 to July 2022. The depressive symptom was defined according to the Hamilton Depression Rating Scale (HAMD). T1-weighted magnetization-prepared rapid acquisition gradient echo (T1 MPRAGE) and pseudo-continuous arterial spin labeling (pCASL) imaging were performed. SPM12 based on MATLAB were used for data processing to generate quantitative cerebral blood flow (CBF) values of each brain region. Independent samples t-test was used to compare regional CBF between PD group and NC group, PD-n group and PD-d group, controlled by false discovery rate correction. The associations between the HAMD score and CBF values of the brain were investigated using partial correlations.Results Compared with the NC group, cerebral blood flow of the right putamen, right hippocampus, right insula and the bilateral parietal lobe, occipital lobe, temporal lobe gray matter and white matter was significantly lower in the PD group (P＜0.05). Cerebral blood flow of the left thalamus, left hippocampus, right cingulate gyrus and the bilateral parietal gray matter, the bilateral occipital white matter was significantly lower in the PD-d group compared with the PD-n group (P＜0.05). Additionally, the CBF value of the right occipital white matter (r=-0.370, P=0.034) and the right cingulate gyrus (r=-0.410, P=0.018) was negative correlated with the HAMD score.Conclusions The arterial spin labeling MRI was used to observe the changes of cerebral perfusion in PD patients, and the hypoperfusion of PD patients in several brain regions may be one of the basic characteristics. Besides, there is a correlation between decreased cerebral perfusion of limbic system and PD with depression.
[Keywords] Parkinson's disease；depression；magnetic resonance imaging；arterial spin labeling；cerebral blood flow

LI Xinyang1, 2   TIAN Yaotian1, 2   WANG Xiaonan1, 2   SU Wen3   LI Shuhua3   MA Xinxin3   LI Chunmei1, 2*   CHEN Min1, 2  

1 Department of Radiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China

2 Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences Beijing 100730, China

3 Department of Neurology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China

Corresponding author: Li CM, E-mail: bee9020@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 82071891).
Received  2022-09-20
Accepted  2022-12-30
DOI: 10.12015/issn.1674-8034.2023.01.002
Cite this article as: LI X Y, TIAN Y T, WANG X N, et al. Cerebral perfusion in Parkinson’s disease with depression: An arterial spin labeling MRI study[J]. Chin J Magn Reson Imaging, 2023, 14(1): 6-12. DOI:10.12015/issn.1674-8034.2023.01.002.

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