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Resting state functional connectivity alterations in motor networks of Parkinson's disease in different frequency bands
ZHANG Pengfei  CHENG Xiu  MA Laiyang  WANG Rui  LI Min  YANG Tingli  GUO Ruiqing  TAO Jiahuan  LIU Guangyao  ZHANG Jing 

Cite this article as: ZHANG P F, CHENG X, MA L Y, et al. Resting state functional connectivity alterations in motor networks of Parkinson's disease in different frequency bands[J]. Chin J Magn Reson Imaging, 2023, 14(1): 13-19. DOI:10.12015/issn.1674-8034.2023.01.003.


[Abstract] Objective Based on resting state functional magnetic resonance imaging (rs-fMRI), to investigate the functional connectivity (FC) of motor networks in Parkinson's disease (PD) patients and to explore frequency-specific FC patterns.Materials and Methods Twenty-eight PD patients and 34 healthy controls (HCs) matched for gender, age, and education were enrolled. A total of 36 regions of interest (ROI) containing the bilateral cerebellum (Ⅳ-Ⅴ, Ⅵ, Ⅷ lobules), substantia nigra (SN), basal ganglia (BG) (caudate nucleus, putamen, pallidum), thalamus, and motor cortex (precentral and postcentral gyrus, paracentral lobule) were selected from atlases to form a PD-specific motor network, using FC in conventional band (0.01-0.1 Hz), slow-3 (0.073-0.198 Hz), slow-4 (0.027-0.073 Hz) and slow-5 (0.01-0.027 Hz) as edges. After network-based statistical analysis, the frequency-specific FC change patterns were explored. Correlations between abnormal FC and clinical motor and cognitive scores were calculated using Spearman's partial correlation analysis.Results PD patients demonstrated extensive FC reduction at conventional band. In the threshold of Pedge=0.01 and Pcomponent=0.05, the component containing 22 ROIs and 29 edges were observed (P=0.017), where inter-network connections were dominated between thalamo-cerebello-BG circuits, as well as connections between SN-putamen and postcentral gyrus-cerebellum. Compared with typical band at the threshold of Pedge=0.05, slow-4 showed more thalamo-BG FC changes, while slow-5 specific FC was mainly the "cerebello-SN-BG-thalamo" related circuits. No statistically aberrant FC was detected in slow-3. The FC between thalamus-pallidum, also between inter-putamina, were negatively correlated with the Unified Parkinson's Disease Rating Scale Ⅲ (UPDRS-Ⅲ) (Pcorrected=0.04 and Pcorrected＜0.01).Conclusions PD patients showed a complex and extensive FC impairment of the integrative motor network, with frequency-specific changes. Alterations in brain functional networks containing "cerebello-SN-BG-thalamo-motor cortical" circuits may be one of the neuropathological mechanisms of PD movement dysfunction. The striatum, thalamus and other subcortical regions may be served as potential biomarkers for disease diagnosis and monitoring.
[Keywords] Parkinson's disease；magnetic resonance imaging；resting-state functional magnetic resonance imaging；functional connectivity；motor network；frequency specificity

ZHANG Pengfei1, 2   CHENG Xiu3   MA Laiyang1, 2   WANG Rui1   LI Min1   YANG Tingli1   GUO Ruiqing1   TAO Jiahuan1   LIU Guangyao1   ZHANG Jing1, 2, 4*  

1 Department of Magnetic Resonance, Lanzhou University Second Hospital, Lanzhou 730030, China

2 Second Clinical School, Lanzhou University, Lanzhou 730030, China

3 Department of Radiology, Shenzhen Bao'an People's Hospital, Shenzhen 518101, China

4 Gansu Province Clinical Research Center for Functional and Molecular Imaging, Lanzhou 730030, China

Corresponding author: Zhang J, E-mail: ery_zhangjing@lzu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81960309); Science and Technology Project of Gansu Province (No. 21JR7RA438).
Received  2022-09-20
Accepted  2023-01-04
DOI: 10.12015/issn.1674-8034.2023.01.003
Cite this article as: ZHANG P F, CHENG X, MA L Y, et al. Resting state functional connectivity alterations in motor networks of Parkinson's disease in different frequency bands[J]. Chin J Magn Reson Imaging, 2023, 14(1): 13-19. DOI:10.12015/issn.1674-8034.2023.01.003.

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