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Resting state functional magnetic resonance imaging observation on the characteristics of spontaneous brain activity and functional connectivity in Parkinson's diseases
XIONG Sining  WAN Na  GUO Rui  SONG Qiuxia  DU Xiangdong  DENG Defeng  AN Jiajia  MA Jing 

Cite this article as: XIONG S N, WAN N, GUO R, et al. Resting state functional magnetic resonance imaging observation on the characteristics of spontaneous brain activity and functional connectivity in Parkinson's diseases[J]. Chin J Magn Reson Imaging, 2023, 14(1): 25-31. DOI:10.12015/issn.1674-8034.2023.01.005.


[Abstract] Objective To observe the characteristics of spontaneous brain activity and connectivity in patients with Parkinson's disease (PD) by resting-state functional magnetic resonance imaging (rs-fMRI) combined with low frequency fluctuation and functional connectivity (FC).Materials and Methods 3.0 T blood oxygenation level dependent (BOLD) rs-fMRI and high-resolution 3D-T1WI scans were obtained from 36 PD patients (PD group) and 31 healthy controls (HC group) matched for age, gender, and education, and then performed image processing and obtained amplitude amplitude of low frequency fluctuation (ALFF), fractional ALFF (fALFF) and percent amplitude of fluctuation (PerAF) values, all results were standardized to obtain mALFF, mfALFF, and mPerAF for statistical analysis and comparison. Seed-based FC was then performed between the differential ALFF, fALFF, and PerAF based brain regions and the rest of the voxels throughout the brain. The correlations between mALFF, mfALFF and mPerAF in abnormal brain region and the Unified Parkinson's Disease Rating Scale (UPDRS) score, the course of disease and Mini-Mental State Examination (MMSE) score in PD patients was analyzed. The images were analyzed and compared by different preprocessing methods to observe the stability of the results.Results Compared with the HC group, the mALFF value of the left precuneus in PD patients was significantly decreased; the mfALFF values of the right medial superior frontal gyrus and left posterior cingulate gyrus were significantly decreased; the mPerAF value of the inferior frontal gyrus was significantly decreased (Alphasim adjusted P＜0.05). In PD group, FC decreased between left precuneus and bilateral angular gyrus, left dorsolateral superior frontal gyrus, and enhanced with right insular operculum inferior frontal gyrus. In the PD group, FC between the left posterior cingulate gyrus and the left precuneus, right middle orbital gyrus, right dorsolateral superior frontal gyrus, right medial superior frontal gyrus, and right angular gyrus was reduced, and FC was enhanced in the right inferior insular gyrus, right supramarginal gyrus, and left medial and paracingulate gyrus (FWE adjusted P＜0.05). The mALFF value of the left precuneus was negatively correlated with the course of disease (r=-0.330, P=0.049), and the mfALFF values of the left posterior cingulate gyrus (r=-0.409, P=0.013) and right medial superior frontal gyrus (r=-0.352, P=0.035) were negatively correlated with the course of disease.Conclusions The combined method of low-frequency fluctuation amplitude and FC of rs-fMRI can more comprehensively show the differential areas in the brain regions of PD patients, mainly stabilized in the default mode network regions and the prefrontal cortex.
[Keywords] Parkinson's disease；magnetic resonance imaging；resting-state functional magnetic resonance imaging；amplitude of low-frequency fluctuations；spontaneous brain activity；functional connectivity

XIONG Sining1   WAN Na1   GUO Rui1   SONG Qiuxia2   DU Xiangdong1   DENG Defeng1   AN Jiajia1   MA Jing1*  

1 Department of Radiology, the Second Affiliated Hospital of Shihezi University (Xinjiang Production and Construction Corps Hospital), Urumqi 830002, China

2 Department of Neurology, the Second Affiliated Hospital of Shihezi University (Xinjiang Production and Construction Corps Hospital), Urumqi 830002, China

Corresponding author: Ma J, E-mail: missingshz@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Financial Science and Technology Program of Xinjiang Production and Construction Corps (No. 2020AB024).
Received  2022-09-19
Accepted  2022-12-30
DOI: 10.12015/issn.1674-8034.2023.01.005
Cite this article as: XIONG S N, WAN N, GUO R, et al. Resting state functional magnetic resonance imaging observation on the characteristics of spontaneous brain activity and functional connectivity in Parkinson's diseases[J]. Chin J Magn Reson Imaging, 2023, 14(1): 25-31. DOI:10.12015/issn.1674-8034.2023.01.005.

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