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• Special Focus •
Research progress of chemical exchange saturation transfer magnetic resonance imaging in neurodegenerative disease
TIAN Yaotian  LI Chunmei  CHEN Min 

Cite this article as: TIAN Y T, LI C M, CHEN M. Research progress of chemical exchange saturation transfer magnetic resonance imaging in neurodegenerative disease[J]. Chin J Magn Reson Imaging, 2023, 14(1): 32-35, 47. DOI:10.12015/issn.1674-8034.2023.01.006.


[Abstract] Chemical exchange saturation transfer (CEST) imaging is a new imaging method developed based on chemical exchange and magnetization transfer technology, which can selectively saturate exchangeable protons in specific metabolites and transfer magnetization to free water. Thus, the signal intensity of specific metabolites can be indirectly reflected by detecting the signal intensity of free water. Based on this, CEST can achieve in vivo non-invasive detection of low concentration of metabolites without the involvement of contrast agents or radioactive tracers, so it has been widely used in central nervous system diseases. Neurodegenerative diseases are an important part of central nervous system diseases. This review will focus on the application and progress of CEST imaging in neurodegenerative diseases.
[Keywords] neurodegenerative disease；Alzheimer's disease；Parkinson's disease；Huntington's disease；amyotrophic lateral sclerosis；multiple sclerosis；magnetic resonance imaging；chemical exchange saturation transfer imaging；amide proton transfer-weighted imaging

TIAN Yaotian1, 2   LI Chunmei1, 2   CHEN Min1, 2*  

1 Department of Radiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China

2 Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China

Corresponding author: Chen M, E-mail: cjr.chenmin@vip.163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 82071891, 81771826).
Received  2022-09-26
Accepted  2023-01-04
DOI: 10.12015/issn.1674-8034.2023.01.006
Cite this article as: TIAN Y T, LI C M, CHEN M. Research progress of chemical exchange saturation transfer magnetic resonance imaging in neurodegenerative disease[J]. Chin J Magn Reson Imaging, 2023, 14(1): 32-35, 47. DOI:10.12015/issn.1674-8034.2023.01.006.

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