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• Clinical Article •
Rs-fMRI study of binary degree centrality and weighted degree centrality changes in the functional brain network in children with self-limited epilepsy with central temporal spikes
JIANG Lin  ZHANG Jiaren  LIU Heng  LI Dongxue  ZHANG Tijiang 

Cite this article as: JIANG L, ZHANG J R, LIU H, et al. Rs-fMRI study of binary degree centrality and weighted degree centrality changes in the functional brain network in children with self-limited epilepsy with central temporal spikes[J]. Chin J Magn Reson Imaging, 2023, 14(1): 36-40, 60. DOI:10.12015/issn.1674-8034.2023.01.007.


[Abstract] Objective Self-limited epilepsy in children with centrotemporal spikes (SeLECTS) is the most common idiopathic focal epilepsy in children and is associated with temporal and spatial changes in resting-state brain network connectivity. This study used resting state fMRI-based binariy degree centrality (DC) and weighted DC method was used to analyze the changes of brain functional network in SeLECTS, so as to explore the potential neurobiological mechanism of SeLECTS.Materials and Methods Resting state functional MRI (rs-fMRI) were collected from 26 SeLECTS patients (SeLECTS group) and 26 healthy volunteers (control group). The rs-fMRI data were processed using the voxel-based brain function network DC method to obtain binary and weighted DC values and to compare the differences in the above parameters within and between the two groups.Results The values of binary DC and weighted DC spatial distributions of SeLECTS group and control group were broadly similar. Compared with healthy controls, the SeLECTS group showed increased binary DC values in the bilateral calcarine cortex, occipital middle cortex, and right fusiform cortex, and decreased binary DC values in the right inferior temporal gyrus and left cerebellum, cerebellar cortex, and superior parietal lobule; the SeLECTS group showed increased weighted DC values in the bilateral calcarine cortex, occipital middle cortex, and right syrinx, and decreased weighted DC values in the right inferior temporal gyrus and left inferior parietal lobule cortex, cerebellum, cerebellar cortex, and precuneus. In addition, correlation analysis showed that, significant positive correlation between the value of binary DC and weighted DC and the epilepsy duration was found in the calcarine cortex (r=0.712, r=0.700, P＜0.001), while significant negative correlation were found in the superior parietal lobule (r=-0.680, r=-0.717, P＜0.001).Conclusions This study suggests that selective and specific disruption of hub nodes, particularly functional network nodes with abnormal configurations of highly connected brain regions, may be associated with the pathogenesis of SeLECTS.
[Keywords] epilepsy self-limited childhood epilepsy with centrotemporal spikes；magnetic resonance imaging；brain functional network；degree centrality

JIANG Lin1*   ZHANG Jiaren1   LIU Heng2   LI Dongxue1   ZHANG Tijiang2  

1 Department of Medical Imaging, the First People's Hospital of Zunyi, the Third Affiliated Hospital of Zunyi Medical University, Zunyi 563000, China

2 Department of Medical Imaging, Affiliated Hospital of Zunyi Medical University, Imaging Centre of Guizhou, Zunyi 563000, China

Corresponding author: Jiang L, E-mail: jlinzmc@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 82160328); Guizhou Provincial Natural Science Foundation (No. Qian Ke He Jichu-ZK〔2021〕Yiban 479); Natural Science Foundation of Zunyi (No. Zun Shi Ke He HZ Zi〔2020〕143); the First People's Hospital of Zunyi Yanjiu Yu Shiyan Fazhan R&D (No. Yuan Ke Zi〔2020〕9).
Received  2022-08-30
Accepted  2022-12-12
DOI: 10.12015/issn.1674-8034.2023.01.007
Cite this article as: JIANG L, ZHANG J R, LIU H, et al. Rs-fMRI study of binary degree centrality and weighted degree centrality changes in the functional brain network in children with self-limited epilepsy with central temporal spikes[J]. Chin J Magn Reson Imaging, 2023, 14(1): 36-40, 60. DOI:10.12015/issn.1674-8034.2023.01.007.

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