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• Clinical Article •
Amplitude of low-frequency fluctuation and regional homogeneity of rs-fMRI in patients with unilateral sudden sensorineural hearing loss
ZHANG Jiajia  LIANG Junjie  WANG Xinru  SHI Anni  LI Yang  BAI Peng 

Cite this article as: ZHANG J J, LIANG J J, WANG X R, et al. Amplitude of low-frequency fluctuation and regional homogeneity of rs-fMRI in patients with unilateral sudden sensorineural hearing loss[J]. Chin J Magn Reson Imaging, 2023, 14(1): 48-53. DOI:10.12015/issn.1674-8034.2023.01.009.


[Abstract] Objective To explore the patients with unilateral sudden sensorineural hearing loss (SSNHL) at the acute stage using resting-state functional magnetic resonance imaging (rs-fMRI) technique with amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo).Materials and Methods A total of 23 patients with unilateral SSNHL at the acute stage and 18 matched healthy controls were selected for rs-fMRI scanning. ALFF and ReHo methods were used to analyze the changes of internal brain activity in patients with unilateral SSNHL, and the correlation between ALFF and ReHo values of brain regions with statistically significant differences and clinical correlation scores were analyzed.Results Compared with the healthy control group, the ALFF value of patients with unilateral SSNHL increased in ipsilateral middle temporal gyrus, insula, superior marginal gyrus and contralateral inferior frontal gyrus, while decreased in contralateral fusiform gyrus, middle temporal gyrus and posterior central gyrus (P＜0.001). ReHo increased in the contralateral inferior cerebellar lobe, ipsilateral middle temporal gyrus and middle frontal gyrus, while decreased in ipsilateral superior occipital gyrus and contralateral middle frontal gyrus (P＜0.001). ALFF values of ipsilateral middle temporal gyrus and superior marginal gyrus were positively correlated with Pure Tone Audiometry (PTA) and Mini-Mental State Examination (MMSE) scores (P＜0.05). The ReHo value of the left middle temporal gyrus was positively correlated with PTA results, and the ReHo value of the left middle frontal gyrus was positively correlated with MMSE score (P＜0.05). There was a positive correlation between the ReHo value of left occipital loop and Self-rating Depression Scale (SDS) score (P＜0.05).Conclusions In the patients with unilateral SSNHL in resting state, there are different degree of brain functional activity changes in auditory and non-auditory parts, mainly involving default network, prominent network and visual and auditory network, which may be related to the pathogenesis of SSNHL.
[Keywords] sensorineural hearing loss；sudden sensorineural hearing loss；magnetic resonance imaging；imaging biomarkers；amplitude of low-frequency fluctuation；regional homogeneity

ZHANG Jiajia1   LIANG Junjie1   WANG Xinru1   SHI Anni2   LI Yang2   BAI Peng1*  

1 Department of Acupuncture, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing 100029, China

2 Department of Acupuncture, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China

Corresponding author: Bai P, E-mail: baipeng1978@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Natural Science Foundation of Beijing (No. 7222283); National TCM Innovation Backbone Talents (National TCM Education Letter No.〔2019〕128).
Received  2022-08-30
Accepted  2022-11-29
DOI: 10.12015/issn.1674-8034.2023.01.009
Cite this article as: ZHANG J J, LIANG J J, WANG X R, et al. Amplitude of low-frequency fluctuation and regional homogeneity of rs-fMRI in patients with unilateral sudden sensorineural hearing loss[J]. Chin J Magn Reson Imaging, 2023, 14(1): 48-53. DOI:10.12015/issn.1674-8034.2023.01.009.

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