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Advanced application of amide proton transfer imaging in female reproductive system
LIU Xinyu  HE Yonglan  XUE Huadan  LI Yuan  JIN Zhengyu 

Cite this article as: LIU X Y, HE Y L, XUE H D, et al. Advanced application of amide proton transfer imaging in female reproductive system[J]. Chin J Magn Reson Imaging, 2023, 14(1): 198-202. DOI:10.12015/issn.1674-8034.2023.01.037.


[Abstract] Amide proton transfer-weighted (APTw) imaging is a method in chemical exchange saturation transfer imaging, which indirectly indicates pH and protein concentration in the tissue based on the proton exchange between amide protons on proteins and polypeptide chains and water protons. APTw imaging, as a new non-invasive magnetic resonance molecular imaging technology, can monitor the changes of protein concentration in early stage to reflect the abnormal proliferation of cells, so as to detect tumors earlier, and can provide important imaging information in uterine body, cervix, and ovarian lesions. It provides help in diagnosis, risk stratification and prognosis, and provides an important reference for clinical treatment. This paper mainly describes the research progress, development prospect and problems to be solved of APTw imaging in female reproductive system.
[Keywords] female reproductive system；uterine neoplasms；cervix neoplasms；ovarian neoplasms；amide proton transfer imaging；magnetic resonance imaging；functional magnetic resonance imaging

LIU Xinyu1   HE Yonglan1   XUE Huadan1   LI Yuan2   JIN Zhengyu1*  

1 Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China

2 Department of Gynecology and Obstetrics, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China

Corresponding author: Jin ZY, E-mail: jin_zhengyu@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81901829).
Received  2022-01-14
Accepted  2022-12-20
DOI: 10.12015/issn.1674-8034.2023.01.037
Cite this article as: LIU X Y, HE Y L, XUE H D, et al. Advanced application of amide proton transfer imaging in female reproductive system[J]. Chin J Magn Reson Imaging, 2023, 14(1): 198-202. DOI:10.12015/issn.1674-8034.2023.01.037.

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