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• Clinical Article •
Application of T1 and T2 weighted ratio to evaluate white matter fibers myelination changes in Alzheimer's disease
ZHU Linlin  WANG Miaomiao  LI Xianjun  WANG Xiaoyu  LIU Congcong  GE Yao  BIAN Yitong  GAO Ling  YANG Jian 

Cite this article as: ZHU L L, WANG M M, LI X J, et al. Application of T1 and T2 weighted ratio to evaluate white matter fibers myelination changes in Alzheimer's disease[J]. Chin J Magn Reson Imaging, 2023, 14(3): 36-41. DOI:10.12015/issn.1674-8034.2023.03.007.


[Abstract] Objective To explore the changes of white matter fibers myelination of Alzheimer's disease (AD) with T1 and T2 weighted ratio.Materials and Methods Based on conventional T1WI and T2WI images, the T1 and T2 weighted ratio mapping was calculated by external calibration methods. The mean T1 and T2 weighted ratio of 20 white matter fiber tracts were extracted. The changes of white matter fibers myelination of 26 patients with AD and 34 healthy control (HC) subjects were compared. The Mini-Mental State Examination (MMSE) was used to evaluate the impairment of intelligence and cognitive function. Two independent samples t-test and Mann-Whitney U test were used to compare the T1 and T2 weighted ratio of white matter fiber tracts between the AD and HC group. Spearman correlation analysis was performed between the T1 and T2 weighted ratio and MMSE scores in AD patients.Results Compared with HC group, the T1 and T2 weighted ratio in AD group showed significant differences in corticospinal tract (CST), cingulum (cingulate gyrus) (CgC), superior longitudinal fasciculus (SLF), right inferior fronto-occipital fasciculus (IFOF), right inferior longitudinal fasciculus (ILF) (P＜0.05). There was no significant correlation between the T1 and T2 weighted ratio and MMSE score in AD patients (P＞0.05).Conclusions The T1 and T2 weighted ratio is a clinically feasible, simple, rapid and non-invasive myelin imaging method. It is a promising candidate index to evaluate the changes of white matter fibers myelination of AD patients, and provides a new idea for the study of the white matter of AD patients.
[Keywords] Alzheimer's disease；white matter；myelination；magnetic resonance imaging；T1 and T2 weighted ratio

ZHU Linlin1   WANG Miaomiao1   LI Xianjun1   WANG Xiaoyu1   LIU Congcong1   GE Yao1   BIAN Yitong1   GAO Ling2   YANG Jian1*  

1 Department of Radiology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China

2 Department of Neurology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China

Corresponding author: Yang J, E-mail: yj1118@mail.xjtu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81971581).
Received  2022-10-24
Accepted  2023-03-03
DOI: 10.12015/issn.1674-8034.2023.03.007
Cite this article as: ZHU L L, WANG M M, LI X J, et al. Application of T1 and T2 weighted ratio to evaluate white matter fibers myelination changes in Alzheimer's disease[J]. Chin J Magn Reson Imaging, 2023, 14(3): 36-41. DOI:10.12015/issn.1674-8034.2023.03.007.

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