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• Clinical Article •
Multiscale brain abnormalities in young male military patients with depression based on resting-state functional magnetic resonance imaging
ZHOU Meng  LI Xianglin  GAO Quansheng 

Cite this article as: ZHOU M, LI X Ｌ, GAO Q S. Multiscale brain abnormalities in young male military patients with depression based on resting-state functional magnetic resonance imaging[J]. Chin J Magn Reson Imaging, 2023, 14(3): 42-47, 64. DOI:10.12015/issn.1674-8034.2023.03.008.


[Abstract] Objective Characterizing multiscale brain function abnormalities in resting-state conditions in young male military patients with major depressive disorder.Materials and Methods Thirty-one young male military depressed patients and healthy control subjects were included in this study. Growth experiences, characteristics, life events, social support, depression, anxiety and concealment scores, and resting-state MRI data were quantitatively collected for all subjects. For the pre-processed functional MRI data, multi-scale feature extraction of the voxel-brain region was combined with general linear models and the Mann-Whitney U to analyze the abnormal characteristics of young male military depressed patients at different scales and the correlations between them and the military psychological data scoring variables.Results (1) On the voxel scale, the amplitude of low-frequency fluctuations (ALFF) in the bilateral lingual gyrus and right frontal superior gyrus, the fractional amplitude of low-frequency fluctuations (fALFF) in the bilateral lingual gyrus and left fusiform, and the functional connectivity strength (FCS) in the left superior temporal lobe were significantly reduced in military depressed patients (P＜0.05); the right paracentral lobule ALFF values, fALFF values of the left frontal middle gyrus and right frontal superior gyrus,and FCS of the left precuneus were significantly higher (P＜0.05). (2) At the brain region scale, patients with major depressive disorder in the military had significantly increased (P＜0.05) betweenness centrality in the right inferior temporal gyrus, degree centrality in the right precuneus and nodal shortest path in the cerebellar vermis; degree centrality, nodal clustering coefficient, and nodal local efficiency in the right inferior temporal gyrus, degree centrality and nodal efficiency in the cerebelum area and nodal local efficiency in the right inferior occipital gyrus were significantly reduced (P＜0.05). (3) At the brain network scale, abnormalities in military depressed patients were found across multiple brain networks, with the default mode network (DMN) and the visual network (VN) showing the most variation. (4) Behavioural correlation analysis revealed that functional characteristics such as ALFF, FCS, degree centrality, nodal efficiency and nodal shortest path in brain regions such as the DMN, VN and cerebellum were significantly correlated with military psychological data variables (P＜0.05).Conclusions This study reveals the characteristics of abnormal changes in brain function at multiple scales, from local to global, in young military patients with depression and uncovers abnormal regions significantly associated with clinical scores. This finding provides results to support further understanding of the pathogenesis of depression in the young male military population.
[Keywords] soldiers major depressive disorder；military psychological data；brain network；voxel；graph theory；resting-state functional magnetic resonance imaging；magnetic resonance imaging

ZHOU Meng1, 2   LI Xianglin1*   GAO Quansheng2*  

1 School of Medical Imaging, Binzhou Medical University, Yantai 264003, China

2 Institute of Environmental and Operational Medicine, Academy of Military Medicial Sciences, Academy of Military Sciences, Tianjin 300050, China

Corresponding author: Li XL, E-mail: xlli@bzmc.edu.cn Gao QS, E-mail: gaoquansheng2022@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 61876188).
Received  2022-12-05
Accepted  2023-03-08
DOI: 10.12015/issn.1674-8034.2023.03.008
Cite this article as: ZHOU M, LI X Ｌ, GAO Q S. Multiscale brain abnormalities in young male military patients with depression based on resting-state functional magnetic resonance imaging[J]. Chin J Magn Reson Imaging, 2023, 14(3): 42-47, 64. DOI:10.12015/issn.1674-8034.2023.03.008.

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