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• Clinical Article •
Early brain functional networks after acute stress: A resting-state fMRI study
ZHAO Na  MENG Linghui  DU Guoshuai  ZHANG Yingdong  LIU Hongran  GAO Minglong  REN Beibei  LIU Furong  ZHANG Li 

Cite this article as: ZHAO N, MENG L H, DU G S, et al. Early brain functional networks after acute stress: A resting-state fMRI study[J]. Chin J Magn Reson Imaging, 2023, 14(3): 48-52. DOI:10.12015/issn.1674-8034.2023.03.009.


[Abstract] Objective To investigate the alterations of functional brain network topology shortly after acute stress using resting-state functional magnetic resonance imaging (rs-fMRI) with graph theory method.Materials and Methods Trauma group involved 36 motor vehicle accidents (MVA) survivors at the Third Hospital of Hebei Medical University between November 2020 and April 2022, and control group recruited 43 gender-, age- and education degree-matched healthy subjects. All subjects got MRI scan and clinical evaluation. MVA survivors received MRI scan and trauma-specific clinical assessments within 1 week from the MVA. Based rs-fMRI with GRETNA (Graph Theoretical Network Analysis) toolbox, Topologic properties of brain functional network were investigated at both global and nodal level. The global level properties included clustering coefficient (Cp); shortest path length (Lp); normalized Cp γ; normalized Lp λ; small-worldness σ, local efficiency (Eloc) and global efficiency (Eg). Group differences in those properties were explored. In MVA group, correlation analyses were peformed to detect the relationship between topologic properties and anxiety scores.Results The functional brain network fitted the definition of small-worldness in MVA survivors and controls. Significantly higher Lp (P=0.001, P＜0.05) and lower Eg (P=0.015, P＜0.05) values were found in MVA survivors as compared with those in control group. There were no statistically significant group differences in Cp、γ、λ、σ　and Eloc (P＞0.05). MVA survivors showed increased nodal centralities in bilateral inferior occipital gyrus (Left, P=0.020; Right, P=0.040; P＜0.05, FDR correction). There was no significant relationship between topologic properties and anxiety scores.Conclusions These results indicate the functional brain network of MVA survivors exhibit small-worldness, but altered global and nodal topological properties shortly after acute stress.
[Keywords] acute stress；brain function；brain network；graph theory；resting-state functional magnetic resonance imaging；magnetic resonance imaging

ZHAO Na1   MENG Linghui1*   DU Guoshuai1   ZHANG Yingdong2   LIU Hongran1   GAO Minglong2   REN Beibei1   LIU Furong3   ZHANG Li4  

1 Department of CT/MRI, the Third Hospital of Hebei Medical University, Shijiazhuang 050000, China

2 Mental Health Center, the First Hospital of Medical University, Shijiazhuang 050000, China

3 Department of CT/MRI, Neiqiu Traditional Chinese Medicine Hospital, Xingtai 054200, China

4 Department of Radiology and Nuclear Medicine, the First Hospital of Hebei Medical University, Shijiazhuang 050000, China

Corresponding author: Meng LH, E-mail: menglhui@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Natural Science Foundation of Hebei Province (No. H2020206278); S&T Program of Hebei (No. 20377734D).
Received  2022-10-13
Accepted  2023-02-23
DOI: 10.12015/issn.1674-8034.2023.03.009
Cite this article as: ZHAO N, MENG L H, DU G S, et al. Early brain functional networks after acute stress: A resting-state fMRI study[J]. Chin J Magn Reson Imaging, 2023, 14(3): 48-52. DOI:10.12015/issn.1674-8034.2023.03.009.

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