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• Clinical Article •
The value of diffusion-relaxation correlation spectrum imaging the in differential diagnosis of early and advanced squamous cervical carcinoma
GAO Yihe  XUE Ke  LI Yan  SU Hui  YE Jing 

Cite this article as: GAO Y H, XUE K, LI Y, et al. The value of diffusion-relaxation correlation spectrum imaging the in differential diagnosis of early and advanced squamous cervical carcinoma[J]. Chin J Magn Reson Imaging, 2023, 14(3): 105-110. DOI:10.12015/issn.1674-8034.2023.03.018.


[Abstract] Objective To evaluate the value of diffusion-relaxation correlation spectrum imaging (DR-CSI) in the differential diagnosis of early and advanced squamous cervical carcinoma (SCC).Materials and Methods Sixty patients with SCC confirmed by pathological biopsy were collected and divided into early-stage and advanced-stage groups according to the International Federation of Gynecology and Obstetrics (FIGO) 2018 staging criteria. T2 weighted imaging (T2WI) sequence and DR-CSI sequence scans were performed preoperatively. DR-CSI sequences were obtained to construct the diffusion-relaxation correlation spectrum (T2-D spectrum), and the T2-D spectrum was divided into six microscopic compartments (A-F). The apparent diffusion coefficient (ADC), transverse relaxation time (T2), and the fraction of compartment (f) were measured for the region of interest (ROI), and the differences in parameters between the two groups were compared using two independent samples t-test or Mann-Whitney U-test. Binary logistic regression analysis was used for multi-parameter joint analysis and receiver operating characteristics (ROC) analysis was used to evaluate the diagnostic efficiency of each parameter and their combinations in distinguishing the early from advanced SCC. The DeLong test was used to compare the significant differences between the area under the curve (AUC) of each parameter and their combinations.Results The fB was the highest in advanced SCC and fC was the highest in early SCC. The ADC and fC in the advanced group were significantly lower than those in the early group, while the fB was significantly higher (P＜0.05). Among single parameters, the fB showed the highest diagnostic efficiency with the AUC (0.818), followed by fC (0.809) and ADC (0.773). By combining the fractions of six compartments compartments (fA-fF), the AUC value was improved to 0.973, which was higher than that of ADC combined with T2 (0.809) and significantly better than that of ADC (0.773) and T2 (0.790) alone (P＜0.05).Conclusions The quantitative parameters of the DR-CSI technique can discriminate early and advanced stage SCC, with better diagnostic performance than conventional ADC and T2, and the combination of multiple parameters is beneficial to improve the differential diagnostic efficacy.
[Keywords] squamous cervical carcinoma；magnetic resonance imaging；diffusion-weighted imaging；apparent diffusion coefficient；T2 mapping；spectrum analysis；differential diagnosis

GAO Yihe1, 2   XUE Ke3   LI Yan1, 2   SU Hui2, 4   YE Jing2*  

1 Dalian Medical University, Dalian 116044, China

2 Department of Imaging, Northern Jiangsu People's Hospital, Yangzhou 225001, China

3 MR Collaboration, Central Research Institute, United Imaging Healthcare, Shanghai 201807, China

4 Yangzhou University, Yangzhou 225001, China

Corresponding author: Ye J, E-mail: 18051061289@163.com

Conflicts of interest   None.

Received  2022-11-08
Accepted  2023-02-28
DOI: 10.12015/issn.1674-8034.2023.03.018
Cite this article as: GAO Y H, XUE K, LI Y, et al. The value of diffusion-relaxation correlation spectrum imaging the in differential diagnosis of early and advanced squamous cervical carcinoma[J]. Chin J Magn Reson Imaging, 2023, 14(3): 105-110. DOI:10.12015/issn.1674-8034.2023.03.018.

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