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Study on the mechanism of high-frequency repetitive transcranial magnetic stimulation in improving memory function of stroke patients by functional magnetic resonance imaging
CHEN Yepeng  XU Shujun  WANG Ping  XING Ruitie  LIU Kun  SUN Li 

Cite this article as: CHEN Y P, XU S J, WANG P, et al. Study on the mechanism of high-frequency repetitive transcranial magnetic stimulation in improving memory function of stroke patients by functional magnetic resonance imaging[J]. Chin J Magn Reson Imaging, 2023, 14(3): 128-133. DOI:10.12015/issn.1674-8034.2023.03.022.


[Abstract] Objective To investigate the effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) on memory function in elderly stroke patients assessed by functional MRI (fMRI).Materials and Methods Ninety elderly stroke patients with memory dysfunction admitted to our hospital were selected as the research objects from January 2021 to December 2021. They were divided into control group (n=45) and observation group (n=45) by random number table method. The control group was given symptomatic treatment, health guidance and routine memory function training, while the observation group was treated with high-frequency rTMS on the basis of the control group. Before and 4 weeks after treatment, the memory function of 2 groups was measured by Rivermead Behavioural Memory Test -Ⅱ (RBMT-Ⅱ), and fMRI scan was performed during the test. The quality of life of patients was assessed by generic quality of life inventory (GQOL-74).Results After 4 weeks of treatment, compared with the control group, the observation group recorded first and last name (t=2.802, P=0.006), stored items (t=2.091, P=0.039), convention (t=2.172, P=0.033), and picture recognition (t=2.174, P=0.032), face recognition (t=2.191, P=0.031), orientation and date (t=3.096, P=0.003), letter immediate recall (t=2.293, P=0.024), story immediate recall (t=2.075, P=0.041) and route immediate recall (t=2.300, P=0.024) scores were higher, and the fMRI amplitude of low frequency fluctuations (ALFF) value in the observation group was higher than that in the control group (t=9.877, P＜0.001). After 4 weeks of treatment, the number of activated brain areas in the observation group was higher than that in the control group, and the score of GQOL-74 questionnaire was higher than that in the control group [physical health (t=3.338, P=0.001), social function (t=3.400, P=0.001), mental health (t=2.221, P=0.029), material life (t=2.298, P=0.024)].Conclusions High frequency rTMS therapy can improve memory function of senile stroke patients with memory dysfunction and improve their quality of life. The fMRI technique was used to prove that its mechanism of action may be related to the enhancement of regional blood flow and nerve activity intensity.
[Keywords] aged；stroke；memory function；magnetic resonance imaging；functional magnetic resonance imaging；high-frequency repetitive transcranial magnetic stimulation；amplitude of low frequency fluctuations

CHEN Yepeng   XU Shujun*   WANG Ping   XING Ruitie   LIU Kun   SUN Li  

Department of Neurology, Daqing Longnan Hospital (the Fifth Affiliated Hospital of Qiqihar Medical College), Daqing 163458, China

Corresponding author: Xu SJ, E-mail: 8989876@qq.com

Conflicts of interest   None.

Received  2022-09-26
Accepted  2023-02-28
DOI: 10.12015/issn.1674-8034.2023.03.022
Cite this article as: CHEN Y P, XU S J, WANG P, et al. Study on the mechanism of high-frequency repetitive transcranial magnetic stimulation in improving memory function of stroke patients by functional magnetic resonance imaging[J]. Chin J Magn Reson Imaging, 2023, 14(3): 128-133. DOI:10.12015/issn.1674-8034.2023.03.022.

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