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Research progress on brain function remodeling mechanism of knee osteoarthritis pain based on resting-state functional magnetic resonance imaging technology
XU Hui  ZHOU Yunfeng  ZHAO Chi  XIE Yuchen  ZHOU Hang  LI Wanyu  GUO Juan 

Cite this article as: XU H, ZHOU Y F, ZHAO C, et al. Research progress on brain function remodeling mechanism of knee osteoarthritis pain based on resting-state functional magnetic resonance imaging technology[J]. Chin J Magn Reson Imaging, 2023, 14(3): 198-202. DOI:10.12015/issn.1674-8034.2023.03.037.


[Abstract] Knee osteoarthritis (KOA) pain makes KOA become one of the main diseases causing functional disability. KOA pain will cause all levels of pain projection neurons in the central nervous system to be in a highly sensitive state, and ultimately induce the functional remodeling of the pain regulation loop in the brain. Resting state functional magnetic resonance imaging (rs-fMRI) makes the mechanism of brain function remodeling of KOA pain intuitive, and provides strong support for the study of central pathological mechanism. Based on the summary of relevant literature in recent 5 years, this paper found that the current research on the mechanism of KOA pain brain function remodeling based on rs-fMRI is mostly focused on local brain regions. It is necessary to further reveal its remodeling mechanism from the perspective of brain function integration with the help of multiple functional and structural imaging methods, and clarify the functional connectivity changes of various brain regions and brain networks caused by KOA pain. This article introduces the development of rs-fMRI and its specific application in the mechanism of KOA pain brain function remodeling, and discusses and prospects its research status, in order to provide new ideas for the clinical management and mechanism research of KOA pain.
[Keywords] knee osteoarthritis；pain；brain；magnetic resonance imaging；functional magnetic resonance imaging；resting-state functional magnetic resonance imaging

XU Hui1, 2   ZHOU Yunfeng2   ZHAO Chi2*   XIE Yuchen3   ZHOU Hang4   LI Wanyu2   GUO Juan2  

1 Department of Tuina, the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450003, China

2 School of Acupuncture-Moxibustion & Tuina, Henan University of Chinese Medicine, Zhengzhou 450046, China

3 Department of Tuina, Henan Provincial Hospital of Traditional Chinese Medicine, Zhengzhou 450003, China

4 MRI Room, the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou 450003, China

Corresponding author: Zhao C, E-mail: zhaochi1216@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81874513); Henan Provincial Science and Technology Research (No. 222102310214); Henan Provincial Special Project for Scientific Research in Traditional Chinese Medicine (No. 2022ZY1108).
Received  2022-06-23
Accepted  2023-02-06
DOI: 10.12015/issn.1674-8034.2023.03.037
Cite this article as: XU H, ZHOU Y F, ZHAO C, et al. Research progress on brain function remodeling mechanism of knee osteoarthritis pain based on resting-state functional magnetic resonance imaging technology[J]. Chin J Magn Reson Imaging, 2023, 14(3): 198-202. DOI:10.12015/issn.1674-8034.2023.03.037.

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