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• Clinical Article •
Changes of functional connectivity density in different severity of nicotine addicts: A functional magnetic resonance imaging study
NIU Xiaoyu  ZHANG Yong  YANG Zhengui  ZHANG Mengzhe  GAO Xinyu  WANG Weijian  CHENG Jingliang 

Cite this article as: NIU X Y, ZHANG Y, YANG Z G, et al. Changes of functional connectivity density in different severity of nicotine addicts: A functional magnetic resonance imaging study[J]. Chin J Magn Reson Imaging, 2023, 14(4): 11-15. DOI:10.12015/issn.1674-8034.2023.04.003.


[Abstract] Objective We aimed to use the functional connectivity density (FCD) method to investigate the common functional brain alterations in the resting state of nicotine addicts, and whether there were more specific brain changes in functional coordination in different severity of nicotine addicts.Materials and Methods A total of 120 nicotine addicts (59 in the mild group and 61 in the severe group) and 56 normal controls underwent resting state magnetic resonance imaging scanning and FCD values were calculated. FCD values were compared among the three groups by ANOVA analysis, and then the differences between the two groups were studied by post-hoc analysis.Results Compared with the control group, both the mild group and the severe group showed decreased FCD in the bilateral calcarine sulcus cortex; only the severe group showed decreased FCD in the right cuneus (voxel level P＜0.005, mass level P＜0.01, Gaussian random field adjusted).Conclusions There were common coordination changes related to the visual attention network in different severity of nicotine addicts, and they persisted with the progression of nicotine dependence. In severe nicotine addicts, the specific brain region of abnormal neural activity was observed. These findings provided new insights into the underlying neural mechanisms of different severity nicotine addicts.
[Keywords] nicotine dependence；substance addiction；visual attention network；attentional bias；functional connectivity density；magnetic resonance imaging

NIU Xiaoyu   ZHANG Yong*   YANG Zhengui   ZHANG Mengzhe   GAO Xinyu   WANG Weijian   CHENG Jingliang  

Department of Magnetic Resonance, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450002, China

Corresponding author: Zhang Y, E-mail: zzuzhangyong2013@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Key Research and Development and Promotion (Science and Technology) Project of Henan Province (No. 212102310712).
Received  2022-05-03
Accepted  2023-04-06
DOI: 10.12015/issn.1674-8034.2023.04.003
Cite this article as: NIU X Y, ZHANG Y, YANG Z G, et al. Changes of functional connectivity density in different severity of nicotine addicts: A functional magnetic resonance imaging study[J]. Chin J Magn Reson Imaging, 2023, 14(4): 11-15. DOI:10.12015/issn.1674-8034.2023.04.003.

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