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• Clinical Article •
Study on quantitative monitoring of occult injury in normal white matter regions of WMHs with different Fazekas based on DTI combined with ASL technique
CHANG Xiaoxia  LI Xiangsheng  JIANG Ruijing  SUN Peng  ZHANG Jinlong  FAN Hongxia 

Cite this article as: CHANG X X, LI X S, JIANG R J, et al. Study on quantitative monitoring of occult injury in normal white matter regions of WMHs with different Fazekas based on DTI combined with ASL technique[J]. Chin J Magn Reson Imaging, 2023, 14(4): 22-28. DOI:10.12015/issn.1674-8034.2023.04.005.


[Abstract] Objective To investigate the value of diffusion tensor imaging (DTI) and arterial spin labelling (ASL) technique in the quantitative evaluation of occult injury in the white matter regions of white matter hyperintensities (WMHs) patients with different Fazekas scores.Materials and Methods The routine MRI, DTI and ASL imaging were performed in 80 cases of WMHs and 30 normal subjects. The functional parameters were compared among different Fazekas scores of WMHs in the normal white matter regions in frontal subcortical, temporal subcortical, anterior horn and trigonal of lateral ventricle, corona radiata and centrum semioval. The patients were divided into three groups according to Fazekas score: Group A (0 point), Group B (1-3 points) and Group C (4-6 points).Results Compared with group A or B, group C had higher apparent diffusion coefficient (ADC) value in bilateral anterior horn of lateral ventricles, trigonal of lateral ventricles and corona radiata regions, and had lower fractional anisotropy (FA)value around bilateral anterior horn of lateral ventricles and trigonal of right lateral ventricle regions (P＜0.05). Group C had lower cerebral blood flow (CBF) around bilateral trigonal of lateral ventricles and corona radiata regions (P＜0.05). The ADC value were negatively correlated with CBF value in the normal white matter area around left frontal subcortical, right corona radiata, right centrum semiovale, anterior horn of bilateral lateral ventricles and trigonal of bilateral lateral ventricles regions (r=-0.326,-0.21,-0.282,-0.443,-0.429,-0.357,-0.383). There was a positive correlation between FA and CBF in the white matter area around the anterior horn of bilateral lateral ventricles regions (r=0.477, 0.268).Conclusions When the WMHs score ranges 4-6 points, DTI combined with ASL imaging can sensitively identify the occult injury in normal white matter areas. The most sensitive area is located in the normal white matter area around the ventricle.
[Keywords] white matter hyperintensity；magnetic resonance imaging；diffusion tensor imaging；arterial spin labeling；Fazekas scale

CHANG Xiaoxia1, 2   LI Xiangsheng2*   JIANG Ruijing2   SUN Peng2   ZHANG Jinlong2   FAN Hongxia2  

1 Hebei North University, Zhangjiakou 075000, China

2 Department of Radiology, Air Force Medical Center of Chinese People's Liberation Army, Beijing 100142, China

Corresponding author: Li XS, E-mail: lxsheng500@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Major Problems in Aeromedicine Science and Technology Project (No. 2020ZTB07).
Received  2022-10-13
Accepted  2023-04-06
DOI: 10.12015/issn.1674-8034.2023.04.005
Cite this article as: CHANG X X, LI X S, JIANG R J, et al. Study on quantitative monitoring of occult injury in normal white matter regions of WMHs with different Fazekas based on DTI combined with ASL technique[J]. Chin J Magn Reson Imaging, 2023, 14(4): 22-28. DOI:10.12015/issn.1674-8034.2023.04.005.

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