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• Clinical Article •
Quantitative assessment of liver and pancreatic fat infiltration and its correlation with insulin resistance in type 2 diabetic patients by 3D-IDEAL-IQ
PENG Xiaoyong  YAN Jun  HUANG Yilong  WANG Haolei  HE Bo 

Cite this article as: PENG X Y, YAN J, HUANG Y L, et al. Quantitative assessment of liver and pancreatic fat infiltration and its correlation with insulin resistance in type 2 diabetic patients by 3D-IDEAL-IQ[J]. Chin J Magn Reson Imaging, 2023, 14(4): 89-94. DOI:10.12015/issn.1674-8034.2023.04.015.


[Abstract] Objective Quantitative assessment of the differences in the content and distribution of fat infiltration in the liver and pancreas between patients with type 2 diabetes mellitus (T2DM) and healthy controls using the iteraterative decomposition of water and fat with echo asymmetry and least-squares estimation quantitation (3D-IDEAL-IQ) technique, and to analyse the correlation between liver and pancreatic fat fraction (FF) and metabolic indicators in the T2DM group.Materials and Methods A total of 57 clinically diagnosed T2DM patients (25 females and 32 males) were recruited prospectively from the First Affiliated Hospital of Kunming Medical University, while 38 healthy controls (20 females and 18 males) were recruited. Upper abdominal MRI scans were performed on all subjects and glucose and lipid testing was completed one day prior to the MRI examination. The glycolipid metabolic indexes of the two groups were recorded separately, and the pancreatic β-cell secretion index HOMA-β (homeostasis model assessment of β cell function) and insulin resistance index HOMA-IR (homeostasis model assessment of insulin resistance) of the T2DM group were calculated, and the glycolipid metabolic indexes of the two groups were recorded separately for correlation analysis. The liver was divided into S1-S8 segments according to the Couinaud segmentation method, while the pancreas was divided into three parts: the head, body and tail of the pancreas. The mean FF of the liver and pancreas between the two groups and the FF of the left and right lobes of the liver were obtained by measuring the FF of each liver segment and the three parts of the pancreas separately by manual segmentation.Results Both the mean FF in the liver and pancreas and the FF in the left and right lobes of the liver and each part of the pancreas were lower in the healthy control group than in the T2DM group (P＜0.001), and the differences in FF in the T2DM group were not statistically significant between the left and right lobes of the liver and between the sites of the pancreas (P=0.713, 0.983). There were statistically significant differences in fasting plasma glucose (FPG), triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) between the two groups (P＜0.001). TG and FPG were higher in the T2DM group than in the healthy control group, while HDL-C were higher in the healthy control group than in the T2DM group. There was a statistical correlation between IR and pancreatic mean FF in the T2DM group, with a moderate positive correlation.Conclusions Ectopic fat deposition in the liver and pancreas of T2DM patients can be assessed using the IDEAL-IQ quantitative technique and the liver and pancreas fat distribution is homogeneous, while HOMA-IR and pancreatic mean FF are correlated.
[Keywords] type 2 diabetes mellitus；liver；pancreas；fat quantification；magnetic resonance imaging

PENG Xiaoyong1, 2   YAN Jun1, 3   HUANG Yilong1   WANG Haolei1   HE Bo1*  

1 Department of Medical Imaging, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China

2 Department of Radiology, Kunming Children's Hospital, Kunming 650103, China

3 Department of Medical Imaging, Qujing First People's Hospital, Qujing 655000, China

Corresponding author: He B, E-mail: 929883137@qq.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 82260338).
Received  2022-11-11
Accepted  2023-04-07
DOI: 10.12015/issn.1674-8034.2023.04.015
Cite this article as: PENG X Y, YAN J, HUANG Y L, et al. Quantitative assessment of liver and pancreatic fat infiltration and its correlation with insulin resistance in type 2 diabetic patients by 3D-IDEAL-IQ[J]. Chin J Magn Reson Imaging, 2023, 14(4): 89-94. DOI:10.12015/issn.1674-8034.2023.04.015.

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