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• Clinical Article •
The value of intravoxel incoherent motion parameters and combined parameters in the diagnosis and clinical staging of cervical cancer
FENG Futing  LEI Zhixin  WANG Wei  CHEN Meining  LUO Min 

Cite this article as: FENG F T, LEI Z X, WANG W, et al. The value of intravoxel incoherent motion parameters and combined parameters in the diagnosis and clinical staging of cervical cancer[J]. Chin J Magn Reson Imaging, 2023, 14(4): 107-111. DOI:10.12015/issn.1674-8034.2023.04.018.


[Abstract] Objective To investigate the value of quantitative parameters and combined parameters of intravoxel incoherent motion (IVIM) diffusion weighted imaging in the pre-treatment diagnosis of cervical cancer and the assessment of different clinical stages of cervical cancer.Materials and Methods Thirty-six patients with cervical squamous cell carcinoma confirmed by pathology and 18 healthy subjects were collected. All subjects underwent IVIM scanning and obtained IVIM parameters: pure apparent diffusion coefficient (D), pseudo-apparent diffusion coefficient (D*) and perfusion fraction (f). All patients were classified into stages Ⅰ, Ⅱ, Ⅲ and Ⅳ according to Federation of International of Gynecologists and Obstetricians (FIGO) staging. <ⅡB stage is early cervical cancer, ≥ⅡB stage is middle-advanced cervical cancer. All data analysis was performed with SPSS 17.0.Results D, D* and f were significantly lower in the cervical cancer group than in the healthy group (P＜0.001). There were significant differences in f between stages (Ⅰ vs. Ⅲ/Ⅳ, Ⅱ vs. Ⅲ/Ⅳ), as well as between early and middle-advanced stages cervical cancer (P＜0.05). The combined parameters D+f and D+f+D* had the best efficacy in identifying cervical cancer with an area under the curve (AUC) of 0.992; D, D+D* and D+f had the best efficacy in identifying early cervical cancer with an AUC of 0.988.Conclusions Quantitative parameters of IVIM can identify cervical cancer before treatment and have better diagnostic efficacy. It is more effective to diagnose cervical cancer or early cervical cancer using the combined parameters. The parameter f has a certain value in the staging of cervical cancer.
[Keywords] cervical cancer；magnetic resonance imaging；intravoxel incoherent motion；clinical staging

FENG Futing1   LEI Zhixin1   WANG Wei1   CHEN Meining2   LUO Min1*  

1 Zigong Fourth People's Hospital, Zigong 643000, China

2 Department of MR Scientific Marketing, Siemens Healthineers, Shanghai 200124, China

Corresponding author: Luo M, E-mail: zghd1234@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Key Research and Development of Zigong Science and Technology Bureau (No. 2019YLSF27).
Received  2022-10-28
Accepted  2023-04-07
DOI: 10.12015/issn.1674-8034.2023.04.018
Cite this article as: FENG F T, LEI Z X, WANG W, et al. The value of intravoxel incoherent motion parameters and combined parameters in the diagnosis and clinical staging of cervical cancer[J]. Chin J Magn Reson Imaging, 2023, 14(4): 107-111. DOI:10.12015/issn.1674-8034.2023.04.018.

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