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Progress of BOLD-fMRI study on rehabilitation of motor dysfunction in ischemic stroke treated with acupuncture
ZHU Li  YU Chengxin 

Cite this article as: ZHU L, YU C X. Progress of BOLD-fMRI study on rehabilitation of motor dysfunction in ischemic stroke treated with acupuncture[J]. Chin J Magn Reson Imaging, 2023, 14(4): 132-136. DOI:10.12015/issn.1674-8034.2023.04.023.


[Abstract] Ischemic stroke (IS) is the leading cause of death and disability in China, with 70% of patients suffering from motor dysfunction, and acupuncture has become a vital early adjuvant therapy. In recent years, blood oxygenation level dependent-functional magnetic resonance imaging has become the most commonly used method to study acupuncture stroke. In this review, a comparison between the research results of regional functional traditional voxel analysis represented by regional homogeneityas well as amplitude of low-frequency fluctuation, and that of complex global cerebral network represented by dynamic functional connection (DFC) analysis as well as graph theoretical analysis were conducted. Also, the research transition of acupuncture treatment for IS motor dysfunction from regional function to global cerebral, from voxel analysis to brain network, and further toward global cerebral network research, together with its merits and limitations were explained. It is proposed that there had been a gradual transition of focus from research on motor completion based on pure sensory motor network (SMN) mapping to that on motor cognition based on default mode network (DMN) mapping, but it was not yet fully popularized. This review provides methodological guidance and theoretical support for the study of acupuncture for IS motor dysfunction, such as flexible use of task design, dual dynamic networks around SMN and DMN, and the use of global cerebral network analysis such as DFC and graph theory to analyze the changes in motor connectivity and properties before and after acupuncture, in order to better explain the acupuncture's rehabilitation mechanism for IS motor dysfunction as clinical guidance.
[Keywords] acupuncture；ischemic stroke；rehabilitation mechanisms of motor function；blood oxygenation level dependent-functional magnetic resonance imaging (BOLD-fMRI)；brain network；movement cognition；magnetic resonance imaging

ZHU Li1, 2   YU Chengxin1, 2*  

1 The First College of Clinical Medical Science, China Three Gorges University, Yichang 443000, China

2 Department of Radiology, Yichang Central People's Hospital, Yichang 443000, China

Corresponding author: Yu CX, E-mail: ycyucx@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Beijing Medical Award Foundation (No. YXJL-2022-0105-0134).
Received  2022-11-01
Accepted  2023-04-05
DOI: 10.12015/issn.1674-8034.2023.04.023
Cite this article as: ZHU L, YU C X. Progress of BOLD-fMRI study on rehabilitation of motor dysfunction in ischemic stroke treated with acupuncture[J]. Chin J Magn Reson Imaging, 2023, 14(4): 132-136. DOI:10.12015/issn.1674-8034.2023.04.023.

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