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• Clinical Article •
Study on resting-state functional magnetic resonance imaging in plateau Tibetan with type 2 diabetes mellitus: Amplitude of low-frequency fluctuations and fractional amplitude of low-frequency fluctuations
HE Wanlin  LI Jinli  FENG Li  HU Xin  GUO Yongyue  HE Yuanyuan  LI Hengyan  ZHU Zhongyuan  MENG Jinli 

Cite this article as: HE W L, LI J L, FENG L, et al. Study on resting-state functional magnetic resonance imaging in plateau Tibetan with type 2 diabetes mellitus: Amplitude of low-frequency fluctuations and fractional amplitude of low-frequency fluctuations[J]. Chin J Magn Reson Imaging, 2023, 14(5): 72-78, 122. DOI:10.12015/issn.1674-8034.2023.05.014.


[Abstract] Objective To explore the differences in regional activity of resting-state functional magnetic resonance imaging (rs-fMRI) between plateau Tibetan with type 2 diabetes mellitus (T2DM) living in a plateau environment and healthy plateau Tibetan, and their relationship with cognitive function.Materials and Methods Fifty-three plateau Tibetan with type 2 diabetes mellitus (PTDM) and 51 plateau Tibetan healthy control (PTHC) in the analysis after age and sex matched were included in this study. Demographic, clinical data, neuropsychological test and rs-fMRI data were collected of both groups, and the rs-fMRI functional indexes the amplitude of amplitude of low-frequency fluctuations (ALFF) and fractional amplitude of low-frequency fluctuation (fALFF) were compared between two groups based on voxels to investigate the differences. We investigated the differences in ALFF and fALFF values between PTDM and PTHC groups and their correlation with demographics, clinical data and neuropsychological test results.Results Compared with the PTHC group, the PTDM group had reduced ALFF values in bilateral cerebellar region Ⅷ ) and reduced fALFF values in the right lingual gyrus and left cerebellar region I (P＜0.05, FWE correction). Correlation analysis showed that the fALFF values of left cerebellar area Ⅷ (r=0.376, P=0.006), right cerebellar area Ⅷ (39, -54, -54) (r=0.411, P=0.002), right cerebellar area Ⅷ (15, -66, -54) (r=0.377, P=0.005) and right lingual gyrus (r=0.337, P=0.014) in the PTDM group were positively correlated with age; in the PTDM group were negatively correlated with low-density cholesterol (r=-0.283, P=0.049), glycated hemoglobin (r=-0.320, P=0.028) and two-hour glucose (r=-0.405, P=0.016). fALFF values of right lingual gyrus in the PTDM group were negatively correlated with Zung's anxiety self-rating scale (r=-0.399, P=0.012); fALFF values of left cerebellar area I in the PTDM group were positively correlated with smoking time (r=0.407, P=0.006), and negatively correlated with Pittsburgh Sleep Quality Index Scale (r=-0.327, P=0.033), Depression Self-Rating Scale (r=-0.320, P=0.041) and patient health questionnaire scores (r=-0.339, P=0.035).Conclusions The rs-fMRI regional activity is reduced in the cerebellum and right lingual gyrus in plateau Tibetan with type 2 diabetes mellitus compared to healthy controls, and correlated with age, glucose indicators, neuropsychology and cognitive function. Exploring the changes in brain function in Tibetan with type 2 diabetes mellitus can provide a better understanding of disease-related changes in cognitive function and related mechanisms.
[Keywords] type 2 diabetes mellitus；plateau Tibetan；amplitude of low-frequency fluctuations；fractional amplitude of low-frequency fluctuations；resting-state magnetic resonance imaging

HE Wanlin1   LI Jinli2   FENG Li1   HU Xin1   GUO Yongyue1   HE Yuanyuan1   LI Hengyan1   ZHU Zhongyuan1   MENG Jinli1, 3*  

1 Department of Radiology, Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region (Hospital C. T.), Chengdu 610041, China

2 Department of Radiology, the People's Hospital of Jianyang City, Chengdu 641499, China

3 Huaxi MR Research Center (HMRRC), West China Hospital, Sichuan University, Chengdu 610041, China

Corresponding author: Meng JL, E-mail: 372042100@qq.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Science and Technology Project of Sichuan Province (No. 2021YJ0161); Medical Research Project of Sichuan Province (No. Q20042); Science and Technology Project of Tibet Autonomous Region: The Central Government Guides Local Projects (No. XZ202102YD0032C); Hospital Level Key Project of Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region (No. 2021-YJ-2).
Received  2022-12-08
Accepted  2023-05-06
DOI: 10.12015/issn.1674-8034.2023.05.014
Cite this article as: HE W L, LI J L, FENG L, et al. Study on resting-state functional magnetic resonance imaging in plateau Tibetan with type 2 diabetes mellitus: Amplitude of low-frequency fluctuations and fractional amplitude of low-frequency fluctuations[J]. Chin J Magn Reson Imaging, 2023, 14(5): 72-78, 122. DOI:10.12015/issn.1674-8034.2023.05.014.

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