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• Clinical Article •
CE HRVW MRI to evaluate diagnostic difference of gadolinium-based contrast agents in intracranial plaque
LI Yanan  SHI Ying  WU Haishan  ZHANG Hongxia  LIU Pengfei 

Cite this article as: LI Y N, SHI Y, WU H S, et al. CE HRVW MRI to evaluate diagnostic difference of gadolinium-based contrast agents in intracranial plaque[J]. Chin J Magn Reson Imaging, 2023, 14(5): 79-84. DOI:10.12015/issn.1674-8034.2023.05.015.


[Abstract] Objective To evaluate the diagnostic efficacy of contrast-enhanced high-resolution vessel wall MRI (CE HRVW MRI) with different gadolinium-based contrast agents (GBCA) in intracranial atherosclerotic plaque quantitatively.Materials and Methods One hundred and five cases of patient with intracranial atherosclerotic disease (ICAD) who underwent CE HRVW MRI examination were analyzed retrospectively and divided into gadobutrol group and Gd-DTPA group. Each enhanced plaque was classified into grade 0, 1 or 2. An objective analysis for each grade had been conducted via comparing the parameters, including signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), contrast enhancement (CE), contrast-to-brain ratio (CBR), and enhancement index (ER) between the two groups.Results One hundred and fifty one plaques were analyzed, in which 69 plaques from 49 patients were detected in gadobutrol group and 82 plaques from 56 patients were detected in Gd-DTPA group. The image quality-related parameters of the three grades between the two groups were compared. The objective evaluation showed that in grade 2 SNR post-contrast [(168.02±26.89) vs. (155.76±18.71)], CNR [(76.14±19.10) vs. (61.83±14.88)], CE [(55.31±19.53) vs. (39.95±15.65)], CBR [(0.85±0.23) vs. (0.68±0.20)], and ER [(117.54±0.34) vs. (101.18±0.18)] were all higher when using gadobutrol compared with Gd-DTPA in CE HR-MRI (P＜0.05). But above parameters of the grade 0 and 1 demonstrated no statistical difference (P＞0.05).Conclusions The diagnostic efficacy of CE HRVW MRI with gadobutrol in intracranial atherosclerotic plaque was superior to that with Gd-DTPA in grade 2 of plaque enhancement.
[Keywords] atherosclerotic；magnetic resonance imaging；vessel wall imaging；gadolinium-based contrast agent；intracranial artery；plaque

LI Yanan   SHI Ying   WU Haishan   ZHANG Hongxia   LIU Pengfei*  

Department of Magnetic Resonance, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, China

Corresponding author: Liu PF, E-mail: liup.fei@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Health Commission of Heilongjiang Province (No. 2020-099); Beiiing New Health Industry Development Foundation.
Received  2022-11-25
Accepted  2023-05-06
DOI: 10.12015/issn.1674-8034.2023.05.015
Cite this article as: LI Y N, SHI Y, WU H S, et al. CE HRVW MRI to evaluate diagnostic difference of gadolinium-based contrast agents in intracranial plaque[J]. Chin J Magn Reson Imaging, 2023, 14(5): 79-84. DOI:10.12015/issn.1674-8034.2023.05.015.

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