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• Clinical Article •
Multi-center study on the prognostic value of cardiac magnetic resonance feature tracking technique for MACE after percutaneous coronary intervention in patients with acute myocardial infarction during hospitalization
ZHANG Yu  LU Lu  XU Junwei  ZHENG Yongqiang  YU Xiaoli  YIN Changqing  WANG Zhi 

Cite this article as: ZHANG Y, LU L, XU J W, et al. Multi-center study on the prognostic value of cardiac magnetic resonance feature tracking technique for MACE after percutaneous coronary intervention in patients with acute myocardial infarction during hospitalization[J]. Chin J Magn Reson Imaging, 2023, 14(5): 123-131. DOI:10.12015/issn.1674-8034.2023.05.022.


[Abstract] Objective To investigate the prognostic value of cardiac magnetic resonance feature tracking (CMR-FT) technique in major cardiovascular adverse events (MACE) in hospital after interventional therapy for acute myocardial infarction (AMI).Materials and Methods Three hundred patients with AMI admitted from January 2019 to October 2022 were selected as study subjects. They were divided into two groups according to whether MACE occurred, namely, MACE group (n=79) and control group (n=221, non MACE group). Both groups of patients underwent percutaneous coronary intervention (PCI) within 12 hours of onset, and CMR was performed 48-72 hours after operation. At the same time, MACE were monitored within 2 weeks of hospitalization. The baseline data and myocardial strain parameters of the two groups were compared. The independent predictors of MACE in the hospital after intervention therapy for AMI were analyzed by Cox regression, and the diagnostic efficacy of myocardial strain parameters was evaluated by drawing the subject's working characteristic curve.Results Cox regression analysis showed that the left ventricular global longitudinal strain [GLS, hazard ratio (HR): 1.24, 95% confidence interval (CI): 1.09-1.37, P＜0.001] and the left ventricular global circumferential strain (GCS, HR: 1.17, 95% CI: 1.08-1.22, P＜0.001) were independent predictors of adverse cardiovascular events after percutaneous coronary intervention in patients with AMI. The diagnostic efficacy of GLS was the best, area under the curve (AUC) was 0.882 (95% CI: 0.706-0.991), and the cut-off value of GLS was -11.9%. When GLS＜-11.9% (less than its absolute value), the incidence of MACE was significantly increased, with sensitivity of 89%, specificity of 82%, and Youden index of 0.80. The diagnostic efficacy of GCS was the second, AUC was 0.735 (95% CI: 0.631-0.958), and the cut-off value of GCS was -17.8%. When GCS＜-17.8% (less than its absolute value), the incidence of MACE was significantly increased, with sensitivity of 78%, specificity of 65%, and Youden index of 0.75. Kaplan-Meier curve analysis showed that the overall survival rate of patients with GLS＜-11.9% was lower than that of patients with GLS≥-11.9% (P＜0.05), and the overall survival rate of patients with GCS＜-17.8% was lower than that of patients with GCS≥-17.8% (P＜0.05).Conclusions CMR-FT technique has a high prognostic value for MACE in the hospital after PCI in AMI, it can assist in early clinical prediction and prevention of MACE during hospitalization after myocardial infarction, and improve the short-term prognosis of patients with myocardial infarction.
[Keywords] coronary heart disease；acute myocardial infarction；major adverse cardiovascular events；magnetic resonance imaging；feature tracking technique；efficacy prediction

ZHANG Yu1   LU Lu2   XU Junwei3*   ZHENG Yongqiang1   YU Xiaoli2   YIN Changqing1   WANG Zhi3  

1 Department of Radiology, the Affiliated Jiangyin Hospital of Nantong University, Jiangyin People's Hospital, Wuxi 214431, China

2 Department of Radiology, Jiangsu Province Hospital of Chinese Medicine, the Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210004, China

3 Department of Cardiology, the Affiliated Brain Hospital of Nanjing Medical University, Nanjing Chest Hospital, Nanjing 210029, China

Corresponding author: Xu JW, E-mail: christxjw@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81570365); Nanjing Medical University Education Development Foundation (No. NMUB2020229).
Received  2022-12-07
Accepted  2023-04-28
DOI: 10.12015/issn.1674-8034.2023.05.022
Cite this article as: ZHANG Y, LU L, XU J W, et al. Multi-center study on the prognostic value of cardiac magnetic resonance feature tracking technique for MACE after percutaneous coronary intervention in patients with acute myocardial infarction during hospitalization[J]. Chin J Magn Reson Imaging, 2023, 14(5): 123-131. DOI:10.12015/issn.1674-8034.2023.05.022.

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