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• Clinical Article •
Comparison of 3D amide proton transfer imaging and intravoxel incoherent motion imaging in the diagnosis of prostate cancer
HOU Guorui  WANG Chen  LI Leilei  LIN Gang  LI Yijun  ZHENG Jianmin 

Cite this article as: HOU G R, WANG C, LI L L, et al. Comparison of 3D amide proton transfer imaging and intravoxel incoherent motion imaging in the diagnosis of prostate cancer[J]. Chin J Magn Reson Imaging, 2023, 14(5): 139-144. DOI:10.12015/issn.1674-8034.2023.05.024.


[Abstract] Objective To investigate the value of 3D amide proton transfer (APT) imaging and intravoxel incoherent motion (IVIM) imaging in the diagnosis and risk assessment of prostate cancer (PCa).Materials and Methods A total of 51 patients with prostate disease in our hospital from April 2022 to November 2022 were prospectively included and divided into 27 patients in the benign prostatic hyperplasia (BPH) group and 24 patients in the PCa group according to pathological puncture or surgical results. According to Gleason score (GS), PCa group was divided into low-risk group (≤6) with 6 cases and high-risk group (≥7) with 18 cases. All patients underwent 3.0 T MRI prostatic examination before surgery. The scans included APT, IVIM, diffusion-weighted imaging (DWI) and other sequences. The areas of interest were delineated on the APT and IVIM parameter images, and the APT value, true diffusion coefficient (D), pseudo diffusion coefficient (D*), perfusion fraction (f) and ADC value of the lesions were measured. Independent sample t test was used to compare the differences of various parameters between BPH group and PCa group, and between PCa high-risk group and low-risk group. Receiver operating characteristic (ROC) curve was used to assess the diagnostic efficiency of each parameter. Spearman correlation analysis was used to analyze the correlation between the parameters and GS.Results The D value and ADC value of BPH group were observably higher than that of PCa group, while the APT value was observably lower than that of PCa group, with statistical significance (P＜0.05). There was no statistical difference in D* and f values between the two groups. D value and ADC value in PCa low-risk group were significantly higher than those in PCa high-risk group, and APT value was significantly lower than those in PCa high-risk group, with statistical significance (P＜0.05). ROC curve analysis showed that the diagnostic specificity of ADC and D values was higher than APT values, while the diagnostic sensitivity of APT and D values was higher than ADC values. Spearman correlation analysis displayed that the ADC value and D value of PCa lesions were significantly negatively correlated with GS (r=-0.691, -0.624; P＜0.001); APT value was significantly positively correlated with GS (r=0.455, P=0.026), while D* value and f value were not correlated with GS (P＞0.05).Conclusions APT and IVIM imaging have certain value in the differential diagnosis of PCa, APT and IVIM D value can provide help for the pathological grading of PCa, and D value is higher.
[Keywords] prostate cancer；pathological grade；Gleason score；magnetic resonance imaging；amide proton transfer imaging；intravoxel incoherent motion；differential diagnosis

HOU Guorui   WANG Chen   LI Leilei   LIN Gang   LI Yijun   ZHENG Jianmin*  

Department of Radiology, Air Force Military Medical University Xijing Hospital, Xi'an 710032, China

Corresponding author: Zheng JM, E-mail: jmzheng1986@126.com

Conflicts of interest   None.

Received  2022-12-19
Accepted  2023-05-06
DOI: 10.12015/issn.1674-8034.2023.05.024
Cite this article as: HOU G R, WANG C, LI L L, et al. Comparison of 3D amide proton transfer imaging and intravoxel incoherent motion imaging in the diagnosis of prostate cancer[J]. Chin J Magn Reson Imaging, 2023, 14(5): 139-144. DOI:10.12015/issn.1674-8034.2023.05.024.

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