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• Clinical Articles •
Application value of DTI in short-term prognosis of patients with branch athero-matous disease
JING Yanping  GUO Zhen'an  SUN Liuyan  WU Lianqiang  WANG Xi  JING Yiwen  CHEN Liwei  WU Xiaofeng  XUE Huiyuan 

Cite this article as: JING Y P, GUO Z A, SUN L Y, et al. Application value of DTI in short-term prognosis of patients with branch athero-matous disease[J]. Chin J Magn Reson Imaging, 2023, 14(7): 32-36, 72. DOI:10.12015/issn.1674-8034.2023.07.006.


[Abstract] Objective To investigate the value of diffusion tensor imaging (DTI) technology in evaluating the integrity and damage degree of perforator atherosclerotic cerebral infarction branch athero-matous disease (BAD) and corticospinal tract (CST), and to help predict clinical prognosis.Materials and Methods A total of 31 cases of patients with BAD from July 2020 to September 2022 were analyzed. According to the National Institutes of Health Stroke Scale (NIHSS) score and Manual Muscle Test (MMT) score, the patients were divided into prediction groups (recovery group, partial recovery group and paralysis group). At the same time, the fractional anisotropy (FA) of the key region of interest (ROI) and the relative position (adjacent, partially through, through) of CST and BAD infarction site were obtained by DTI, patients were predicted as recovery (relative adjacent), partial recovery (relative partial crossing) and paralysis (relative through); NIHSS score and MMT score were performed at 1, 2, and 4 weeks after treatment, and the evaluation results were taken as the actual values. Pearson correlation analysis and partial correlation analysis were performed to explore the correlation between FA value, CST extent of damage and NIHSS and MMT score, and multivariate linear stepwise regression analysis was used to verify the linear quantitative relationship.Results The FA and apparent diffusion coefficient (ADC) images of 31 patients showed good structure and clear structure. The FA value of the infarct and the corresponding normal brain tissue on the mirror side decreased, and the ADC value decreased, t values were 2.836 and 2.107, and P values were 0.015 and 0.010, respectively, and the differences were significant (P＜0.05). The reconstruction of the corticospinal tract was good, and the visualization rate of the left and right corticospinal tracts was 100%. After fiber bundle reconstruction, 10 patients showed CST adjacent to the infarct but did not cross the infarct. These patients had a good prognosis, and their muscle strength recovered quickly and the recovery degree was obvious. In 11 patients, CST partially passed through the infarct. The prognosis of these patients was slightly worse, and the recovery of muscle strength was slightly worse. All the 10 patients had CST through the infarct. The prognosis of these patients was poor, the course of disease was long, and the muscle strength decreased significantly. Correlation analysis showed that NIHSS score, MMT predicted score and actual score after treatment were positively correlated with FA value of the affected side (all P＜0.05). Multiple linear stepwise regression was performed. The relative position of the affected side CST and the BAD infarct site (adjacent, partially through, and through) had a linear regression relationship with the score of the recovery group, partial recovery group, and paralysis group.Conclusions DTI technology can effectively evaluate the integrity of BAD and CST, and the evaluation results are highly positively correlated with clinical prediction and actual prognosis, which can provide a basis for clinical treatment and prognosis assessment.
[Keywords] branch athero-matous disease；diffusion tensor imaging；magnetic resonance imaging；corticospinal tract；National Institutes of Health Stroke Scale

JING Yanping1*   GUO Zhen'an1   SUN Liuyan1   WU Lianqiang1   WANG Xi1   JING Yiwen1   CHEN Liwei2   WU Xiaofeng2   XUE Huiyuan2  

1 Image Center, Yellow River Sanmenxia Hospital Affiliated to Henan University of Science and Technology, Sanmenxia 472000, China

2 Department of Neurology, Yellow River Sanmenxia Hospital Affiliated to Henan University of Science and Technology, Sanmenxia 472000, China

Corresponding author: Jing YP, E-mail: jingyanping5858@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Medical and Health Industry Fund Project of Power China Construction Group (No. 2022036).
Received  2022-10-28
Accepted  2023-06-25
DOI: 10.12015/issn.1674-8034.2023.07.006
Cite this article as: JING Y P, GUO Z A, SUN L Y, et al. Application value of DTI in short-term prognosis of patients with branch athero-matous disease[J]. Chin J Magn Reson Imaging, 2023, 14(7): 32-36, 72. DOI:10.12015/issn.1674-8034.2023.07.006.

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