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• Clinical Articles •
Application of magnetization transfer imaging combined with DWI and T2WI in diagnosis and grading of prostate cancer
AI Guangyong  QIAO Xiaofeng  SHU Xin  LIU Yunfan  LI Xin  NIU Shengwen  HUANG Xin  FANG Jing  ZHANG Rong  HE Xiaojing 

Cite this article as: AI G Y, QIAO X F, SHU X, et al. Application of magnetization transfer imaging combined with DWI and T2WI in diagnosis and grading of prostate cancer[J]. Chin J Magn Reson Imaging, 2023, 14(7): 86-92. DOI:10.12015/issn.1674-8034.2023.07.015.


[Abstract] Objective To determine the value of magnetization transfer imaging (MTI) in diagnosing prostate cancer (PCa) and assessing the histologic grade.Materials and Methods This study was conducted prospectively. A total of 134 patients with clinical suspicion of PCa underwent biparametric MRI with magnetization transfer (MTr) technology, and followed by biopsy or radical prostatectomy. According to the results of pathologic diagnosis, all patients were divided into two groups PCa and benign prostatic hyperplasia (BPH). The patients in PCa group were divided into low- and high score groups (Ls group and Hs group) based on the new Gleason grade groups (GGG) system. The feasibility of MTr in prostate imaging is evaluated. The magnetization transfer ratio (MTR) were compared between the PCa group and BPH group, and prior to the different grade in PCa group. The efficacy of T2WI and diffusion-weighted imaging (DWI) sequences with or without MTr pulse in the diagnosis of PCa and the stratification of low- or high-grade PCa was compared.Results After applying MTr technology, the image quality of T2WI and DWI images were optimized. There was high consistency of MTR measure between intraobserver and interobserver. After MTr pulse was applied to DWI sequence, the diagnostic efficacy of PCa (pre-MTr AUC=0.779, post-MTr AUC=0.850) and the differentiation of Ls and Hs (pre-sMTr AUC=0.697, post-MTr AUC=0.818) were effectively improved. Measured the MTR between BPH and PCa group, a significant difference between groups was found in the DWI sequence trial (t=-1.85, P=0.06), but not in the T2 sequence trial (t=-3.39, P=0.01). Measured the MTR between Ls group and Hs group, a statistically insignificant difference was found in the T2WI sequence trial (t=-0.53, P=0.59), but not in the DWI sequence trial (t=3.42, P=0.01).Conclusions MTI can improve the performance for the PCa detect and identify high grade lesions, especially the MTR in DWI sequence showed great potential in diagnosing and grading PCa.
[Keywords] prostate；benign prostatic hyperplasia；prostate cancer；magnetic resonance imaging；magnetization transfer；gleason grade groups；classification

AI Guangyong1, 2   QIAO Xiaofeng1, 2   SHU Xin1, 2   LIU Yunfan1, 2   LI Xin1, 2   NIU Shengwen1, 2   HUANG Xin1, 2   FANG Jing1, 2   ZHANG Rong1, 2   HE Xiaojing1, 2*  

1 Department of Radiology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China

2 The Second Clinical College of Chongqing Medical University, Chongqing 400010, China

Corresponding author: He XJ, E-mail: he_xiaojing@hospital.cqmu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS Science and Health Joint Medical Research Project of Chongqing (No. 2019GDRC011).
Received  2022-09-01
Accepted  2023-06-28
DOI: 10.12015/issn.1674-8034.2023.07.015
Cite this article as: AI G Y, QIAO X F, SHU X, et al. Application of magnetization transfer imaging combined with DWI and T2WI in diagnosis and grading of prostate cancer[J]. Chin J Magn Reson Imaging, 2023, 14(7): 86-92. DOI:10.12015/issn.1674-8034.2023.07.015.

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