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• Clinical Articles •
The value of apparent diffusion coefficient minimum in differential diagnosis of early prostate cancer and chronic prostatitis in peripheral zone
FANG Lei  FANG Hui  JIN Li  LIU Xinjiang 

Cite this article as: FANG L, FANG H, JIN L, et al. The value of apparent diffusion coefficient minimum in differential diagnosis of early prostate cancer and chronic prostatitis in peripheral zone[J]. Chin J Magn Reson Imaging, 2023, 14(7): 93-97. DOI:10.12015/issn.1674-8034.2023.07.016.


[Abstract] Objective To explore the value of apparent diffusion coefficient minimum (ADCmin) in differential diagnosis of early prostate cancer (PCa) and chronic prostatitis in peripheral zone.Materials and Methods The MRI data of 65 patients of early PCa and 39 patients of chronic prostatitis with pathology confiemed were retrospectively analyzed, the lesions were all located in the peripheral zone of prostate, the mean apparent diffusion coefficient (ADCmean) and ADCmin of the parenchyma of the lesion were measured, the difference of ADCmean and ADCmin between the two groups were analyzed. The receiver operating characteristic (ROC) curve and DeLong test were used to evaluate and compare the diagnostic efficiency of ADCmean and ADCmin for early PCa and chronic prostatitis in peripheral zone.Results The ADCmean and ADCmin in the early PCa group were lower than those in the chronic prostatitis group, and differences between groups were statistically significant (P＜0.001). The area under the curve (AUC) of ADCmean and ADCmin were 0.888 and 0.935, there was statistical difference in diagnostic performance by DeLong test (P＜0.05). The optimal cut-off value of ADCmean was 1.008×10-3 mm2/s, the sensitivity and specificity or the diagnosis of early PCa were 81.54%, 94.87%, respectively. The optimal cut-off value of ADCmin was 0.861×10-3 mm2/s, the sensitivity and specificity for the diagnosis of early PCa were 83.08%, 94.87%, respectively.Conclusions The diagnostic efficacy of ADCmin in differentiating early PCa and chronic prostatitis in the peripheral zone is better than that of ADCmean, which has good clinical reference value.
[Keywords] prostatic neoplasms；prostate cancer；chronic prostatitis；magnetic resonance imaging；apparent diffusion coefficient

FANG Lei   FANG Hui   JIN Li   LIU Xinjiang*  

Department of Radiology, Pudong Hospital, Fudan University, Shanghai 201399, China

Corresponding author: Liu XJ, E-mail: lxj6513@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Special Item of Clinical Research on Health Industry of Shanghai Health Commission (No. 202140266); Discipline Construction Project of Shanghai Pudong New Area Health System (No. PWZbr2022-16).
Received  2023-01-02
Accepted  2023-06-25
DOI: 10.12015/issn.1674-8034.2023.07.016
Cite this article as: FANG L, FANG H, JIN L, et al. The value of apparent diffusion coefficient minimum in differential diagnosis of early prostate cancer and chronic prostatitis in peripheral zone[J]. Chin J Magn Reson Imaging, 2023, 14(7): 93-97. DOI:10.12015/issn.1674-8034.2023.07.016.

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