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• Clinical Articles •
Clinical value of diffusion tensor imaging in polymyositis and dermatomyositis
JIANG Weili  HUANG Yin  LONG Bin  BAI Yuhan  ZHANG Wei  ZHANG Dongyou 

Cite this article as: JIANG W L, HUANG Y, LONG B, et al. Clinical value of diffusion tensor imaging in polymyositis and dermatomyositis[J]. Chin J Magn Reson Imaging, 2023, 14(7): 103-107. DOI:10.12015/issn.1674-8034.2023.07.018.


[Abstract] Objective To investigate the diffusion tensor imaging (DTI) of thigh muscles in patients with polymyositis (PM) and dermatomyositis (DM).Materials and Methods Forty-six patients with PM/DM diagnosed in our hospital from September 2019 to March 2022 were selected as PM/DM group. Thirty-two healthy volunteers who came to our hospital at the same time without muscle diseases were selected as control group. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were compared among the PM/DM edema muscles, unaffected muscles (non-edema muscles) and normal muscles of ROI region. The one way analysis of variance test, receiver operating characteristic (ROC) curve and Spearman rank correlation analyses were used to analysis the mean ADC, FA of DTI in PM/DM group and control group. P values＜0.05 were considered statistically significant.Results The mean ADC value of edema muscles in the PM/DM group was higher on average and showed a statistically significant difference when compared with unaffected muscles and normal muscles (P＜0.05), while the mean ADC value was no statistical difference between unaffected muscles and normal muscles (P＞0.05). There was no significant difference in the mean FA value between the three groups (P＞0.05).The optimal cut-off value of ADC between edema muscles and normal muscles was 1.62×10-3 mm2/s, sensitivity was 87.5%, specificity was 85.0% and AUC was 0.869. Correlation analysis showed that mean ADC value of edema muscles were positively correlated with creatine kinase (CK; r=0.583, P＜0.001), but there was no significant correlation between mean FA value of edema muscles with CK (P＞0.05).Conclusions DTI can be used to quantitatively analyze pathological features of edema muscles in patients with PM/DM, DTI can be a good ability for diagnose PM/DM.
[Keywords] polymyositis；dermatomyositis；magnetic resonance imaging；diffusion tensor imaging；quantitative analysis；diagnostic

JIANG Weili1   HUANG Yin2   LONG Bin1   BAI Yuhan1   ZHANG Wei1*   ZHANG Dongyou1  

1 Department of Radiology, Wuhan No.1 Hospital, Wuhan 430022, China

2 Department of Dermatology, Wuhan No.1 Hospital, Wuhan 430022, China

Corresponding author: Zhang W, E-mail: zhangweikj328@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Wuhan Medical Research Project (No. WX21Z62).
Received  2022-09-27
Accepted  2023-06-28
DOI: 10.12015/issn.1674-8034.2023.07.018
Cite this article as: JIANG W L, HUANG Y, LONG B, et al. Clinical value of diffusion tensor imaging in polymyositis and dermatomyositis[J]. Chin J Magn Reson Imaging, 2023, 14(7): 103-107. DOI:10.12015/issn.1674-8034.2023.07.018.

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