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• Clinical Article •
Comparative study on the application of Dixon and SPAIR in thyroid-associated ophthalmopathy
HUANG Kai  LIN Xiaoxin  LUO Yaosheng  HU Qiugen  GUO Baoliang  OUYANG Fusheng  OUYANG Yufeng  SONG Cheng  CHEN Haixiong 

HUANG K, LIN X X, LUO Y S, et al. Comparative study on the application of Dixon and SPAIR in thyroid-associated ophthalmopathy[J]. Chin J Magn Reson Imaging, 2023, 14(8): 51-57. DOI:10.12015/issn.1674-8034.2023.08.008.


[Abstract] Objective To compare the image quality and application value of water-fat separation (Dixon) and spectral attenuated inversion recovery (SPAIR) MRI fat suppression techniques in thyroid-associated ophthalmopathy (TAO).Materials and Methods This cross-sectional retrospective study included 73 TAO patients (146 eyes) who underwent orbital MRI including Dixon and SPAIR fat suppression sequences from 2020 to 2022. We compared the fat suppression effect, artifacts, noise, signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR) and diagnostic efficacy of TAO activity between T2WI-Dixon aqueous phase and T2WI-SPAIR images.Results In terms of the overall image quality of MRI, the proportion of T2WI-Dixon aqueous phase images superior to T2WI-SPAIR images was higher (67.1% vs. 13.7%). The fat suppression effect, artifact score and noise of T2WI-Dixon aqueous phase were significantly lower than those of T2WI-SPAIR images (Z: 6.632-10.473, P＜0.001), SNR and CNR were significantly higher than those of T2WI-SPAIR images (Z: -8.792--10.482, P＜0.001). The correlation between extraocular muscle/white matter signal intensity ratio (EOM-SIR), lacrimal gland/white matter signal intensity ratio (LG-SIR) and clinical activity score (CAS) in T2WI-Dixon water phase images was higher than that in T2WI-SPAIR image (0.613 vs. 0.520; 0.282 vs. 0.251). The AUC of EOM-SIR and LG-SIR of T2WI-Dixon water phase in evaluating TAO activity was higher than that of T2WI-SPAIR image (0.872 vs. 0.772; 0.673 vs. 0.604), the difference was statistically significant (Z=4.070, P＜0.001; Z=2.174, P=0.030).Conclusions The image quality of T2WI-Dixon was better than that of T2WI-SPAIR. In addition, T2WI-Dixon water has a stronger ability to evaluate the inflammatory edema of TAO retrobulbar tissue than T2WI-SPAIR images, and has higher diagnostic efficiency for TAO diagnosis and activity staging. Dixon technique provides an excellent fat suppression technique for MRI examination of TAO patients.
[Keywords] thyroid-associated ophthalmopathy；fat-suppression；image quality；Dixon；spectral attenuated inversion recovery；magnetic resonance imaging

HUANG Kai1   LIN Xiaoxin1   LUO Yaosheng2   HU Qiugen1   GUO Baoliang1   OUYANG Fusheng1   OUYANG Yufeng1   SONG Cheng2   CHEN Haixiong1*  

1 Department of Radiology, Shunde Hospital, Southern Medical University, Foshan 528308, China

2 Department of Endocrinology, Shunde Hospital, Southern Medical University, Foshan 528308, China

Corresponding author: Chen HX, E-mail: 13825553451@139.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Medical Scientific and Technology Research Foundation of Guangdong Province of China (No. B2022185); Foshan Self-Raised Funds of Science and Technology Plan Projects (No. 2220001003987); Research Initiation Program of Shunde Hospital, Southern Medical University (Key Specialty-Cultivation Project) (No. SRSP2021037).
Received  2023-04-02
Accepted  2023-07-21
DOI: 10.12015/issn.1674-8034.2023.08.008
HUANG K, LIN X X, LUO Y S, et al. Comparative study on the application of Dixon and SPAIR in thyroid-associated ophthalmopathy[J]. Chin J Magn Reson Imaging, 2023, 14(8): 51-57. DOI:10.12015/issn.1674-8034.2023.08.008.

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