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• Clinical Article •
The value of radiomics model based on ZOOMit DWI in the diagnosis of clinically significant prostate cancer
QIAO Xiaomeng  BAO Jie  HU Chenhan  CAO Changhao  HU Chunhong  WANG Ximing 

QIAO X M, BAO J, HU C H, et al. The value of radiomics model based on ZOOMit DWI in the diagnosis of clinically significant prostate cancer[J]. Chin J Magn Reson Imaging, 2023, 14(8): 79-85. DOI:10.12015/issn.1674-8034.2023.08.013.


[Abstract] Objective To compare the value between the radiomics models based on zoomed imaging technique with parallel transmission diffusion weighted imaging (ZOOMit DWI) and readout segmentation of long variable echo-trains (RESOLVE) DWI for the diagnosis of clinically significant prostate cancer (csPCa).Materials and Methods A total of 168 patients were included in this retrospective study, including 83 cases of csPCa and 85 cases of non-csPCa. The patients were grouped randomly into a training set (n=117) and a test set (n=51) in a ratio of 7∶3. Optimal radiomics features were selected by using Pearson correlation coefficient (PCC) method, analysis of variance (ANOVA) and least absolute shrinkage and selection operator (LASSO) regression with 10-fold cross-validation in the training set. Logistic regression was used to develop the models. The single sequence radiomics models were built to predict csPCa including ZOOMit DWI, ZOOMit apparent diffusion coefficient (ADC), RESOLVE DWI and RESOLVE ADC. The bi-parametric MRI (bpMRI) radiomics models was built combining DWI sequence with better diagnostic performance and T2-weighted imaging (T2WI). The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic performance of the radiomics models. The DeLong test was performed to statistically compare areas under the curve (AUC).Results In the test group, ZOOMit DWI had higher AUC than RESOLVE DWI (0.917 vs. 0.851, P=0.022); ZOOMit ADC had higher AUC than RESOLVE ADC, of borderline statistical significance (0.948 vs. 0.871, P=0.052). The bpMRI radiomics models was established based on T2WI, ZOOMit DWI and ZOOMit ADC. The AUC of the bpMRI radiomics model was 0.937 in the test set, which was significantly higher than that of prostate-specific antigen (PSA) (0.792, P=0.012).Conclusions The radiomics models based on the ZOOMit DWI sequence had better diagnostic performance for csPCa than those based on the RESOLVE DWI sequence. The bpMRI radiomics model combined ZOOMit DWI sequence and T2WI showed great diagnostic value for csPCa.
[Keywords] clinically significant prostate cancer；diffusion weighted imaging；radiomics；magnetic resonance imaging；diagnostic performance

QIAO Xiaomeng   BAO Jie   HU Chenhan   CAO Changhao   HU Chunhong   WANG Ximing*  

Department of Radiology, First Affiliated Hospital of Soochow University, Suzhou 215006, China

Corresponding author: Wang XM, E-mail: wangximing1998@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Medical and Health Science and Technology Innovation Program in Suzhou (No. SKY2022003); Special Program for Diagnosis and Treatment Technology of Clinical Key Diseases in Suzhou (No. LCZX202001).
Received  2022-08-26
Accepted  2023-06-29
DOI: 10.12015/issn.1674-8034.2023.08.013
QIAO X M, BAO J, HU C H, et al. The value of radiomics model based on ZOOMit DWI in the diagnosis of clinically significant prostate cancer[J]. Chin J Magn Reson Imaging, 2023, 14(8): 79-85. DOI:10.12015/issn.1674-8034.2023.08.013.

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