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Research progress of magnetic resonance 3D-T1 weighted imaging and diffusion tensor imaging in tremor-dominant Parkinson's disease
LI Qian  QIU Lihua 

LI Q, QIU L H. Research progress of magnetic resonance 3D-T1 weighted imaging and diffusion tensor imaging in tremor-dominant Parkinson's disease[J]. Chin J Magn Reson Imaging, 2023, 14(8): 124-128. DOI:10.12015/issn.1674-8034.2023.08.021.


[Abstract] Parkinson's disease (PD) is a prevalent neurodegenerative condition characterized by progressive motor dysfunction that can lead to reduced daily activities, diminished quality of life, and eventual disability. To evaluate the underlying structural changes in PD patients, three dimensions T1-weighted imaging (3D-T1WI) and diffusion-tensor imaging (DTI) in structural MRI are utilized to provide a quantitative analysis of microstructural changes in gray matter and white matter, respectively. In recent years, research utilizing 3D-T1WI has implicated tremor in the tremor-dominant (TD) PD subtype, particularly in the hippocampus, parafascicular and ventral intermediate nucleus of the thalamus, pallidumand and cerebellum. DTI has revealed white matter changes in TD subtype patients mainly affecting the inferior fronto-occipital fasciculi, inferior longitudinal fasciculi, corticospinal tract and left dentatorubrothalamic tract, which closely related to the point of origin and treatment of tremor symptoms. This paper presents a review of the imaging principles and analysis methods utilized in the study of TD subtypes with 3D-T1WI and DTI, offering a foundation and guidance for future research.
[Keywords] Parkinson's disease；tremor-dominant；three dimensions T1-weighted imaging；diffusion-tensor imaging；gray matter；white matter

LI Qian1, 2   QIU Lihua1, 2, 3*  

1 Department of Radiology, the First Affiliated Hospital of Chengdu Medical College, Chengdu 610500, China

2 Medical Imaging Center, the Second People's Hospital of Yibin, Yibin 644000, China

3 Neuroimaging Big Data Research Center, Clinical Medical Research and Transformation Center, Second People's Hospital of Yibin City-West China Yibin Hospital, Yibin 644000, China

Corresponding author: Qiu L H, E-mail: qlh20050616@foxmail.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Key Research and Development Program of China (No. 2022YFC2009900, 2022YFC2009901); Project of Sichuan Medical Association (No. S19020).
Received  2023-03-01
Accepted  2023-07-27
DOI: 10.12015/issn.1674-8034.2023.08.021
LI Q, QIU L H. Research progress of magnetic resonance 3D-T1 weighted imaging and diffusion tensor imaging in tremor-dominant Parkinson's disease[J]. Chin J Magn Reson Imaging, 2023, 14(8): 124-128. DOI:10.12015/issn.1674-8034.2023.08.021.

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