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Basic principle of time-dependent diffusion MRI and its application in prostate cancer
XU Ting  LIU Xiaowen  PENG Yongjia  CHEN Yaxi  GONG Jingshan 

XU T, LIU X W, PENG Y J, et al. Basic principle of time-dependent diffusion MRI and its application in prostate cancer[J]. Chin J Magn Reson Imaging, 2023, 14(8): 171-175. DOI:10.12015/issn.1674-8034.2023.08.030.


[Abstract] Prostate cancer (PCa) is a kind of tumor with high morbidity, mortality and heterogeneity, which seriously affects the health of elderly men and brings social problems of overdiagnosis and excessive treatment. MRI is the preferred imaging method for the diagnosis, guidance of biopsy and monitoring of prostate diseases. Conventional diffusion-weighted imaging can not obtain the characteristics of cellular scale diffusion of water molecules caused by clinical significant PCa microstructure changes, which has some limitations in the diagnosis of PCa. However, time-dependent diffusion MRI (TDD-MRI) using oscillating gradient spin-echo (OGSE) can obtain the characteristics of cell-scale diffusion of water molecules to reflect the microstructure of prostate nodules in vivo, which shows the potential to be a non-invasive and easily available imaging biomarker for the diagnosis and risk stratification of PCa, and to provide decision making support for personalized therapy of PCa. This paper mainly introduces the basic principle of TDD-MRI and its application in PCa, and discusses whether TDD-MRI can be used as a non-invasive and easily obtained imaging biomarker in vivo for the diagnosis and risk stratification of PCa, so as to provide decision support for personalized medical treatment of clinical PCa.
[Keywords] prostate cancer；diffusion-weighted imaging；time-dependent diffusion magnetic resonance imaging；oscillating gradient spin-echo；precision medicine；magnetic resonance imaging

XU Ting1   LIU Xiaowen1   PENG Yongjia1   CHEN Yaxi1   GONG Jingshan2*  

1 The Second Clinical Medical College of Jinan University, Shenzhen 518020, China

2 Department of Radiology, Shenzhen People's Hospital, the Second Clinical Medical College of Jinan University, the First Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518020, China

Corresponding author: Gong JS, E-mail: jshgong@sina.com

Conflicts of interest   None.

Received  2022-08-15
Accepted  2023-06-25
DOI: 10.12015/issn.1674-8034.2023.08.030
XU T, LIU X W, PENG Y J, et al. Basic principle of time-dependent diffusion MRI and its application in prostate cancer[J]. Chin J Magn Reson Imaging, 2023, 14(8): 171-175. DOI:10.12015/issn.1674-8034.2023.08.030.

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