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• Clinical Article •
A study of regional homogeneity altered of brain function and cognitive dysfunction in patients with ischemic stroke
DING Jurong  LI Yuan  HUA Bo  FENG Chenyu  TANG Zhiling  YANG Chenghao  DING Xin 

DING J R, LI Y, HUA B, et al. A study of regional homogeneity altered of brain function and cognitive dysfunction in patients with ischemic stroke[J]. Chin J Magn Reson Imaging, 2023, 14(9): 7-12. DOI:10.12015/issn.1674-8034.2023.09.002.


[Abstract] Objective To explore the changes of regional homogeneity (ReHo) of resting-state brain activity in patients with ischemic stroke (IS) and its relationship with cognitive dysfunction.Materials and Methods Twenty patients with IS and 27 age- and sex- matched healthy controls were prospectively enrolled. All subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI) scan and ReHo analysis. The group differences were compared by using two-sample t test. Person correlation analysis was used to analyze the correlation between the abnormal ReHo values and the scores of mini-mental state examination (MMSE) and Montreal cognitive assessment (MoCA) scale in IS patient group.Results Compared with the healthy control group, the IS patient group showed reduced in ReHo values in the right middle frontal gyrus, postcentral gyrus, middle temporal gyrus and the left inferior frontal gyrus, triangular part. The increased in ReHo values were found in the bilateral supplementary motor area, median cingulate and paracingulate gyri, the left superior parietal gyrus, precuneus and paracentral lobule. The group differences were statistically significant (P＜0.001, AlphaSim corrected). In addition, the increased ReHo value in the bilateral supplementary motor area and left superior parietal gyrus showed a significant negative correlation with MMSE score (r=-0.640, P=0.014; r=-0.541, P=0.046; r=-0.563, P=0.036).Conclusions The spontaneous ReHo changes exist in multiple brain regions in patients with IS, which may be related to cognitive dysfunction. ReHo values in abnormal brain regions may be an important biomarker of IS.
[Keywords] ischemic stroke；brain activity；regional homogeneity；cognitive dysfunction；resting-state functional magnetic resonance imaging；magnetic resonance imaging

DING Jurong1, 2*   LI Yuan1, 2   HUA Bo1, 2   FENG Chenyu1, 2   TANG Zhiling1, 2   YANG Chenghao3   DING Xin4  

1 College of Automation and Information Engineering, Sichuan University of Science & Engineering, Yibin 644000, China

2 Artificial Intelligence Key Laboratory of Sichuan Province, Sichuan University of Science & Engineering, Yibin 644000, China

3 Department of Neurosurgery, Zigong Fourth People's Hospital, Zigong 643000, China

4 Department of Neurology, Chengdu Second People's Hospital, Chengdu 610000, China

Corresponding author: Ding JR, E-mail: jurongding@gmail.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81401482); Artificial Intelligence Key Laboratory of Sichuan Province Open Fund (No. 2021RYJ08); Foundation of Chengdu Municipal Health Commission (No. 2022151).
Received  2023-04-12
Accepted  2023-09-06
DOI: 10.12015/issn.1674-8034.2023.09.002
DING J R, LI Y, HUA B, et al. A study of regional homogeneity altered of brain function and cognitive dysfunction in patients with ischemic stroke[J]. Chin J Magn Reson Imaging, 2023, 14(9): 7-12. DOI:10.12015/issn.1674-8034.2023.09.002.

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