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• Clinical Article •
Abnormal changes of brain function in patients with OSAHS: VMHC-based rs-fMRI study
JI Lirong  WANG Erlei  CHEN Rui  WANG Jing  YA Yang  SU Tong  CHENG Chaohong  FAN Guohua 

JI L R, WANG E L, CHEN R, et al. Abnormal changes of brain function in patients with OSAHS: VMHC-based rs-fMRI study[J]. Chin J Magn Reson Imaging, 2023, 14(9): 13-18. DOI:10.12015/issn.1674-8034.2023.09.003.


[Abstract] Objective To explore the alterations of voxel-mirrored homotopic connectivity (VMHC) in obstructive sleep apnea-hypopnea syndrome (OSAHS) patients and the correlations with clinical indicators.Materials and Methods In this study, apnea hypopnea index (AHI) 15 was taken as the cut-off value, and the subjects were divided into moderate or severe group (OSAHS group, n=68), normal or mild group (control group, n=47). All subjects were male, and underwent polysomnography (PSG) monitoring, cambridge neuropsychological test automated battery assessment, structural and resting-state functional MRI scans. Compared the differences in VMHC between the two groups, and the VMHC values of the abnormal brain regions were extracted to perform the partial correlation analysis with PSG and Cambridge cognitive indicators.Results Compared with the control group, the OSAHS group showed significantly increased VMHC in bilateral posterior cingulate gyrus, insula and superior temporal gyrus (GRF corrected, voxel level P＜0.001, cluster level P＜0.05, two tailed). The VMHC value of bilateral posterior cingulate gyrus and insula were positively correlated with the selection time of spatial recognition memory (SRM) (r=0.318, P=0.010; r=0.437, P＜0.001).Conclusions Patients with OSAHS presente increased VMHC in specific brain regions, suggesting the compensatory mechanism of brain function, and there are certain correlations between the abnormal brain changes and cognitive impairment.
[Keywords] obstructive sleep apnea-hypopnea syndrome；resting-state functional magnetic resonance imaging；voxel-mirrored homotopic connectivity；cognitive impairment；brain functional impairment

JI Lirong1   WANG Erlei1   CHEN Rui2   WANG Jing2   YA Yang1   SU Tong2   CHENG Chaohong2   FAN Guohua1*  

1 Department of Radiology, the Second Affiliated Hospital of Soochow University, Suzhou 215000, China

2 Department of Respiratory, the Second Affiliated Hospital of Soochow University, Suzhou 215000, China

Corresponding author: Fan GH, E-mail: fangh22@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 82070095); Suzhou Municipal Science and Technology Project (No. SKY2022011); Elderly Health Research Project of Jiangsu Province (No. LKZ2022009); Pre-research Fund Project for Young Employees of the Second Affiliated Hospital of Soochow University (No. SDFEYLC2245); Science and Technology Project for "Star of Medical Imaging" of Suzhou Medical Association (No. 2022YX-M03).
Received  2022-01-11
Accepted  2023-09-06
DOI: 10.12015/issn.1674-8034.2023.09.003
JI L R, WANG E L, CHEN R, et al. Abnormal changes of brain function in patients with OSAHS: VMHC-based rs-fMRI study[J]. Chin J Magn Reson Imaging, 2023, 14(9): 13-18. DOI:10.12015/issn.1674-8034.2023.09.003.

[1]
BENJAFIELD A V, AYAS N T, EASTWOOD P R, et al. Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis[J]. Lancet Respir Med, 2019, 7(8): 687-698. DOI: 10.1016/S2213-2600(19)30198-5.
[2]
LIGUORI C, MAESTRI M, SPANETTA M, et al. Sleep-disordered breathing and the risk of Alzheimer's disease[J/OL]. Sleep Med Rev, 2021, 55: 101375 [2022-01-10]. https://pubmed.ncbi.nlm.nih.gov/33022476/. DOI: 10.1016/j.smrv.2020.101375.
[3]
PURTLE M W, RENNER C H, MCCANN D A, et al. Driving with undiagnosed obstructive sleep apnea (OSA): high prevalence of OSA risk in drivers who experienced a motor vehicle crash[J]. Traffic Inj Prev, 2020, 21(1): 38-41. DOI: 10.1080/15389588.2019.1709175.
[4]
WANG Q, CHEN G B, AO F, et al. Study on brain dysfunction and its mechanism in patients with obstructive sleep apnea hypopnea syndrome based on rs-fMRI degree centrality method[J]. Radiol Pract, 2021, 36(12): 1474-1480. DOI: 10.13609/j.cnki.1000-0313.2021.12.004.
[5]
DUAN W W, LIU X, PING L L, et al. Distinct functional brain abnormalities in insomnia disorder and obstructive sleep apnea[J]. Eur Arch Psychiatry Clin Neurosci, 2023, 273(2): 493-509. DOI: 10.1007/s00406-022-01485-7.
[6]
ZHANG Q, QIN W, HE X X, et al. Functional disconnection of the right anterior insula in obstructive sleep apnea[J]. Sleep Med, 2015, 16(9): 1062-1070. DOI: 10.1016/j.sleep.2015.04.018.
[7]
WANG Z Q, WANG J L, ZHANG H, et al. Interhemispheric functional and structural disconnection in Alzheimer's disease: a combined resting-state fMRI and DTI study[J/OL]. PLoS One, 2015, 10(5): e0126310 [2022-01-10]. https://pubmed.ncbi.nlm.nih.gov/25938561/. DOI: 10.1371/journal.pone.0126310.
[8]
YANG H, WANG C W, JI G J, et al. Aberrant interhemispheric functional connectivity in first-episode, drug-naïve major depressive disorder[J]. Brain Imaging Behav, 2019, 13(5): 1302-1310. DOI: 10.1007/s11682-018-9917-x.
[9]
LI H W, ZHOU M, ZHUO L H, et al. Analysis of voxel-mirrored homotopic connectivity in first-episode drug-naive adolescent onset schizophrenia[J]. J Pract Radiol, 2021, 37(11): 1759-1762. DOI: 10.3969/j.issn.1002-1671.2021.11.004.
[10]
LIU Y T, ZHANG H X, LI H J, et al. Aberrant interhemispheric connectivity in obstructive sleep apnea-hypopnea syndrome[J/OL]. Front Neurol, 2018, 9: 314 [2022-01-10]. https://pubmed.ncbi.nlm.nih.gov/29867724/. DOI: 10.3389/fneur.2018.00314.
[11]
ROBBINS T W, JAMES M, OWEN A M, et al. Cambridge Neuropsychological Test Automated Battery (CANTAB): a factor analytic study of a large sample of normal elderly volunteers[J]. Dementia, 1994, 5(5): 266-281. DOI: 10.1159/000106735.
[12]
ROBBINS T W, JAMES M, OWEN A M, et al. A study of performance on tests from the CANTAB battery sensitive to frontal lobe dysfunction in a large sample of normal volunteers: implications for theories of executive functioning and cognitive aging. Cambridge Neuropsychological Test Automated Battery[J]. J Int Neuropsychol Soc, 1998, 4(5): 474-490. DOI: 10.1017/s1355617798455073.
[13]
CABEZA R, ALBERT M, BELLEVILLE S, et al. Maintenance, reserve and compensation: the cognitive neuroscience of healthy ageing[J]. Nat Rev Neurosci, 2018, 19(11): 701-710. DOI: 10.1038/s41583-018-0068-2.
[14]
BARIL A A, GAGNON K, BRAYET P, et al. Gray matter hypertrophy and thickening with obstructive sleep apnea in middle-aged and older adults[J]. Am J Respir Crit Care Med, 2017, 195(11): 1509-1518. DOI: 10.1164/rccm.201606-1271OC.
[15]
ZHOU L, LIU G Q, LUO H, et al. Aberrant hippocampal network connectivity is associated with neurocognitive dysfunction in patients with moderate and severe obstructive sleep apnea[J/OL]. Front Neurol, 2020, 11: 580408 [2022-01-10]. https://pubmed.ncbi.nlm.nih.gov/33362692/. DOI: 10.3389/fneur.2020.580408.
[16]
KANG D J, QIN Z Y, WANG W, et al. Brain functional changes in Tibetan with obstructive sleep apnea hypopnea syndrome: a resting state fMRI study[J/OL]. Medicine, 2020, 99(7): e18957 [2022-01-10]. https://pubmed.ncbi.nlm.nih.gov/32049791/. DOI: 10.1097/MD.0000000000018957.
[17]
ZHU Y Q, FENG Z Y, XU J L, et al. Increased interhemispheric resting-state functional connectivity after sleep deprivation: a resting-state fMRI study[J]. Brain Imaging Behav, 2016, 10(3): 911-919. DOI: 10.1007/s11682-015-9490-5.
[18]
ZHOU L, CHEN P, PENG Y T, et al. Role of oxidative stress in the neurocognitive dysfunction of obstructive sleep apnea syndrome[J/OL]. Oxid Med Cell Longev, 2016, 2016: 9626831 [2022-01-10]. https://pubmed.ncbi.nlm.nih.gov/27774119/. DOI: 10.1155/2016/9626831.
[19]
JOO E Y, TAE W S, LEE M J, et al. Reduced brain gray matter concentration in patients with obstructive sleep apnea syndrome[J]. Sleep, 2010, 33(2): 235-241. DOI: 10.1093/sleep/33.2.235.
[20]
MACEY P M, KUMAR R, WOO M A, et al. Brain structural changes in obstructive sleep apnea[J]. Sleep, 2008, 31(7): 967-977. DOI: 10.5665/sleep/31.7.967.
[21]
XIN H Z, PENG D C, CHEN L T, et al. Separation of functional connections on the anterior and posterior default network in patients with obstructive sleep apnea[J]. J Clin Radiol, 2019, 38(8): 1371-1375. DOI: 10.13437/j.cnki.jcr.2019.08.001.
[22]
LI H J, DAI X J, GONG H H, et al. Aberrant spontaneous low-frequency brain activity in male patients with severe obstructive sleep apnea revealed by resting-state functional MRI[J/OL]. Neuropsychiatr Dis Treat, 2015, 11: 207-214 [2022-01-10]. https://pubmed.ncbi.nlm.nih.gov/25653530/. DOI: 10.2147/NDT.S73730.
[23]
LEECH R, SHARP D J. The role of the posterior cingulate cortex in cognition and disease[J]. Brain, 2014, 137(Pt 1): 12-32. DOI: 10.1093/brain/awt162.
[24]
LUCEY B P, MCCULLOUGH A, LANDSNESS E C, et al. Reduced non-rapid eye movement sleep is associated with tau pathology in early Alzheimer's disease[J/OL]. Sci Transl Med, 2019, 11(474): eaau6550 [2022-01-10]. https://pubmed.ncbi.nlm.nih.gov/30626715/. DOI: 10.1126/scitranslmed.aau6550.
[25]
IBRAHIM B, SUPPIAH S, IBRAHIM N, et al. Diagnostic power of resting-state fMRI for detection of network connectivity in Alzheimer's disease and mild cognitive impairment: a systematic review[J]. Hum Brain Mapp, 2021, 42(9): 2941-2968. DOI: 10.1002/hbm.25369.
[26]
JOO E Y, JEON S, KIM S T, et al. Localized cortical thinning in patients with obstructive sleep apnea syndrome[J]. Sleep, 2013, 36(8): 1153-1162. DOI: 10.5665/sleep.2876.
[27]
KANG J, TIAN Z S, LI M X. Changes in insular cortex metabolites in patients with obstructive sleep apnea syndrome[J]. Neuroreport, 2018, 29(12): 981-986. DOI: 10.1097/WNR.0000000000001065.
[28]
LI H J, PENG D C, GONG H H, et al. Frequency-dependent alterations in the amplitude of low frequency fluctuations in patients with obstructive sleep apnea syndrome: a resting-state functional MRI study[J]. J Clin Radiol, 2016, 35(3): 323-327. DOI: 10.13437/j.cnki.jcr.2016.03.003.
[29]
KANG D J, BAO H H, QIN Z Y, et al. fMRI study of brain structure and function in obstructive sleep apnea hypopnea syndrome[J]. J Pract Radiol, 2019, 35(1): 6-10. DOI: 10.3969/j.issn.1002-1671.2019.01.002.
[30]
LI H J, LI L, KONG L H, et al. Frequency-specific regional homogeneity alterations and cognitive function in obstructive sleep apnea before and after short-term continuous positive airway pressure treatment[J/OL]. Nat Sci Sleep, 2021, 13: 2221-2238 [2022-01-10]. https://pubmed.ncbi.nlm.nih.gov/34992481/. DOI: 10.2147/NSS.S344842.
[31]
TAYLOR K S, MILLAR P J, MURAI H, et al. Cortical autonomic network gray matter and sympathetic nerve activity in obstructive sleep apnea[J/OL]. Sleep, 2018, 41(2): zsx208 [2022-01-10]. https://pubmed.ncbi.nlm.nih.gov/29309669/. DOI: 10.1093/sleep/zsx208.

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