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• Clinical Article •
Abnormal changes of brain function in patients with OSAHS: VMHC-based rs-fMRI study
JI Lirong  WANG Erlei  CHEN Rui  WANG Jing  YA Yang  SU Tong  CHENG Chaohong  FAN Guohua 

JI L R, WANG E L, CHEN R, et al. Abnormal changes of brain function in patients with OSAHS: VMHC-based rs-fMRI study[J]. Chin J Magn Reson Imaging, 2023, 14(9): 13-18. DOI:10.12015/issn.1674-8034.2023.09.003.


[Abstract] Objective To explore the alterations of voxel-mirrored homotopic connectivity (VMHC) in obstructive sleep apnea-hypopnea syndrome (OSAHS) patients and the correlations with clinical indicators.Materials and Methods In this study, apnea hypopnea index (AHI) 15 was taken as the cut-off value, and the subjects were divided into moderate or severe group (OSAHS group, n=68), normal or mild group (control group, n=47). All subjects were male, and underwent polysomnography (PSG) monitoring, cambridge neuropsychological test automated battery assessment, structural and resting-state functional MRI scans. Compared the differences in VMHC between the two groups, and the VMHC values of the abnormal brain regions were extracted to perform the partial correlation analysis with PSG and Cambridge cognitive indicators.Results Compared with the control group, the OSAHS group showed significantly increased VMHC in bilateral posterior cingulate gyrus, insula and superior temporal gyrus (GRF corrected, voxel level P＜0.001, cluster level P＜0.05, two tailed). The VMHC value of bilateral posterior cingulate gyrus and insula were positively correlated with the selection time of spatial recognition memory (SRM) (r=0.318, P=0.010; r=0.437, P＜0.001).Conclusions Patients with OSAHS presente increased VMHC in specific brain regions, suggesting the compensatory mechanism of brain function, and there are certain correlations between the abnormal brain changes and cognitive impairment.
[Keywords] obstructive sleep apnea-hypopnea syndrome；resting-state functional magnetic resonance imaging；voxel-mirrored homotopic connectivity；cognitive impairment；brain functional impairment

JI Lirong1   WANG Erlei1   CHEN Rui2   WANG Jing2   YA Yang1   SU Tong2   CHENG Chaohong2   FAN Guohua1*  

1 Department of Radiology, the Second Affiliated Hospital of Soochow University, Suzhou 215000, China

2 Department of Respiratory, the Second Affiliated Hospital of Soochow University, Suzhou 215000, China

Corresponding author: Fan GH, E-mail: fangh22@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 82070095); Suzhou Municipal Science and Technology Project (No. SKY2022011); Elderly Health Research Project of Jiangsu Province (No. LKZ2022009); Pre-research Fund Project for Young Employees of the Second Affiliated Hospital of Soochow University (No. SDFEYLC2245); Science and Technology Project for "Star of Medical Imaging" of Suzhou Medical Association (No. 2022YX-M03).
Received  2022-01-11
Accepted  2023-09-06
DOI: 10.12015/issn.1674-8034.2023.09.003
JI L R, WANG E L, CHEN R, et al. Abnormal changes of brain function in patients with OSAHS: VMHC-based rs-fMRI study[J]. Chin J Magn Reson Imaging, 2023, 14(9): 13-18. DOI:10.12015/issn.1674-8034.2023.09.003.

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