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• Clinical Article •
Changes in spontaneous brain activity in patients with postherpetic neuralgia: An ALE Meta-analysis based on rs-fMRI data
QIU Zhiqiang  ZHONG Xiangkai  YANG Qiming  SHI Xiran  XU Xiaoxue 

QIU Z Q, ZHONG X K, YANG Q M, et al. Changes in spontaneous brain activity in patients with postherpetic neuralgia: An ALE Meta-analysis based on rs-fMRI data[J]. Chin J Magn Reson Imaging, 2023, 14(9): 19-25. DOI:10.12015/issn.1674-8034.2023.09.004.


[Abstract] Objective To explore the characteristics of spontaneous brain activity changes in patients with postherpetic neuralgia (PHN), so as to reveal the possible neural mechanism of PHN, and lay a foundation for the objective evaluation of the therapeutic effect of PHN through the changes of spontaneous brain activity in the later stage.Materials and Methods PubMed, The Cochrane Library, EMBase, Medine, and Web of Science, CNKI, CBM, VIP database and Wanfang Data Knowledge service Platform were searched for literatures, which study the changes of brain basal activity in patients with PHN using regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) /fractional amplitude of low-frequency fluctuation (fALFF) analysis methods. Activation likelihood estimation (ALE) was used to perform a Meta-analysis of the brain regions with spontaneous brain activity changes in PHN patients compared with healthy controls (HCs).Results A total of 16 studies from 11 articles were included, including 5 ReHo studies, 4 ALFF studies and 7 fALFF studies, with a total of 200 PHN patients and 236 HCs. Combined with the data from the ALFF/fALFF and ReHo studies, the Meta-analysis results showed that compared with HCs, PHN patients had increased spontaneous brain activity in the right middle frontal gyrus, right thalamus, left striatum and right cuneus, while decreased spontaneous brain activity in the right temporal lobe and right parahippocampal gyrus. Meta-analysis using ALFF/fALFF data alone showed that compared with HCs, PHN patients had increased spontaneous brain activity in the right middle frontal gyrus, right thalamus and left striatum, but no decreased spontaneous brain activity was found. Meta-analysis using data from ReHo study alone showed that there were no regions with increased or decreased spontaneous brain activity in PHN patients compared with HCs.Conclusions In this paper, through the ALE Meta-analysis method, based on the data of reported rs-fMRI whole brain studies, we find that PHN patients have spontaneous brain activity changes in the right middle frontal gyrus, right thalamus, left striatum, right cuneus, right temporal lobe and right parahippocampal gyrus. This provides an important basis for objective evaluation of PHN treatment efficacy through changes in spontaneous brain activity.
[Keywords] postherpetic neuralgia；spontaneous brain activity；resting state functional magnetic resonance imaging；Meta analysis；activation likelihood estimation；magnetic resonance imaging

QIU Zhiqiang   ZHONG Xiangkai   YANG Qiming   SHI Xiran   XU Xiaoxue*  

Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China

Corresponding author: Xu XX, E-mail: nclittlesnownc@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Clinical Key Specialty Construction Manuscript [No. (2023)87]; Science and Technology Project of Sichuan Health Commission (No. 23LCYJ019).
Received  2023-02-24
Accepted  2023-08-09
DOI: 10.12015/issn.1674-8034.2023.09.004
QIU Z Q, ZHONG X K, YANG Q M, et al. Changes in spontaneous brain activity in patients with postherpetic neuralgia: An ALE Meta-analysis based on rs-fMRI data[J]. Chin J Magn Reson Imaging, 2023, 14(9): 19-25. DOI:10.12015/issn.1674-8034.2023.09.004.

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