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• Clinical Article •
White matter microstructural changes shortly after acute stress: A DTI study
ZHAO Na  MENG Linghui  ZHANG Yingdong  DU Guoshuai  LIU Hongran  GAO Minglong  REN Beibei 

ZHAO N, MENG L H, ZHANG Y D, et al. White matter microstructural changes shortly after acute stress: A DTI study[J]. Chin J Magn Reson Imaging, 2023, 14(9): 39-43. DOI:10.12015/issn.1674-8034.2023.09.007.


[Abstract] Objective To investigate the changes of white matter microstructure shortly after acute stress using diffusion tensor imaging (DTI) and discuss the clinical significance of these changes.Materials and Methods Thirty motor vehicle accident (MVA) survivors and 26 gender, age and education degree matched healthy subjects were recruited. Along with MRI scan, clinical assessments were also evaluated in both groups. MVA survivors got trauma-specific clinical assessments including Hamilton Anxiety Scale (HAMA) score and received MRI scan within 1week from the MVA. Tract-based spatial statistics (TBSS) was carried out to investigate difference in white matter integrity between 2 groups. White matter integrity was measured using fractional anisotropy (FA), axial diffusivity (AD) and radical diffusivity (RD). A correlation between HAMA score and regional FA value was examined using correlation analysis.Results Significantly lower FA (P＜0.05) values with higher RD (P＜0.05) values were found in areas including the left external capsule, posterior limb of internal capsule, superior longitudinal fasciculus and posterior thalamic radiations (including optic radiation) in MVA survivors as compared with those in control group (P＜0.05). No AD changes were noted (P＞0.05). HAMA score was negatively correlated with FA in the left posterior thalamic radiations (including optic radiation)( r=-0.40, P=0.03 ).Conclusions These results indicate changes in white matter microstructure integrity shortly after acute stress which may be related to anxiety symptom. Therefore, highlight the need for early evaluation and intervention for trauma survivors.
[Keywords] acute stress；magnetic resonance imaging；diffusion tensor imaging；white matter；tract-based spatial statistics

ZHAO Na1   MENG Linghui1*   ZHANG Yingdong2   DU Guoshuai1   LIU Hongran1   GAO Minglong2   REN Beibei1  

1 Department of CT/MRI, the Third Hospital of Hebei Medical University, Shijiazhuang 050051, China

2 Mental Health Center, the First Hospital of Hebei Medical University, Shijiazhuang 050030, China

Corresponding author: Meng LH, E-mail: menglhui@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Natural Science Foundation of Hebei Province (No. H2020206278); S&T Program of Hebei (No. 20377734D).
Received  2023-03-28
Accepted  2023-08-04
DOI: 10.12015/issn.1674-8034.2023.09.007
ZHAO N, MENG L H, ZHANG Y D, et al. White matter microstructural changes shortly after acute stress: A DTI study[J]. Chin J Magn Reson Imaging, 2023, 14(9): 39-43. DOI:10.12015/issn.1674-8034.2023.09.007.

[1]
BENJET C, BROMET E, KARAM E G, et al. The epidemiology of traumatic event exposure worldwide: results from the World Mental Health Survey Consortium[J]. Psychol Med, 2016, 46(2): 327-343. DOI: 10.1017/s0033291715001981.
[2]
LIU H, PETUKHOVA M V, SAMPSON N A, et al. Association of DSM-IV Posttraumatic Stress Disorder With Traumatic Experience Type and History in the World Health Organization World Mental Health Surveys[J]. JAMA Psychiatry, 2017, 74(3): 270-281. DOI: 10.1001/jamapsychiatry.2016.3783.
[3]
ROBERTS N P, KITCHINER N J, KENARDY J, et al. Early psychological intervention following recent trauma: A systematic review and meta-analysis[J]. Eur J Psychotraumatol, 2019, 10(1): 1695486. DOI: 10.1080/20008198.2019.1695486.
[4]
HU H, ZHOU Y, WANG Q, et al. Association of abnormal white matter integrity in the acute phase of motor vehicle accidents with post-traumatic stress disorder[J]. J Affect Disord, 2016, 190: 714-722. DOI: 10.1016/j.jad.2015.09.044.
[5]
SOLMI M, RADUA J, OLIVOLA M, et al. Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies[J]. Mol Psychiatry, 2022, 27(1): 281-295. DOI: 10.1038/s41380-021-01161-7.
[6]
MOLENDOWSKA M, MATUSZEWSKI J, KOSSOWSKI B, et al. Temporal Dynamics of Brain White Matter Plasticity in Sighted Subjects during Tactile Braille Learning: A Longitudinal Diffusion Tensor Imaging Study[J]. J Neurosci. 2021, 41(33): 7076-7085. DOI: 10.1523/JNEUROSCI.2242-20.2021.
[7]
MUNYESHYAKA M, FIELDS R D. Oligodendroglia are emerging players in several forms of learning and memory[J]. Commun Biol, 2022, 5(1): 1148. DOI: 10.1038/s42003-022-04116-y.
[8]
VAN DER WERFF S J A, ELZINGA B M, SMIT A S, et al. Structural brain correlates of resilience to traumatic stress in Dutch police officers[J]. Psychoneuroendocrinology, 2017, 85: 172-178. DOI: 10.1016/j.psyneuen.2017.08.019.
[9]
O'DOHERTY D C M, RYDER W, PAQUOLA C, et al. White matter integrity alterations in post-traumatic stress disorder[J]. Hum Brain Mapp, 2018, 39(3): 1327-1338. DOI: 10.1002/hbm.23920.
[10]
ADMON R, LEYKIN D, LUBIN G, et al. Stress-induced reduction in hippocampal volume and connectivity with the ventromedial prefrontal cortex are related to maladaptive responses to stressful military service[J]. Hum Brain Mapp, 2013, 34(11): 2808-2816. DOI: 10.1002/hbm.22100.
[11]
WONG S A, LEBOIS L A M, ELY T D, et al. Internal capsule microstructure mediates the relationship between childhood maltreatment and PTSD following adulthood trauma exposure[J/OL]. Mol Psychiatry, 2023 [2023-03-27]. https://www.nature.com/articles/s41380-023-02012-3. DOI: 10.1038/s41380-023-02012-3.
[12]
SMITH S M, JENKINSON M, WOOLRICH M W, et al. Advances in functional and structural MR image analysis and implementation as FSL[J]. Neuroimage, 2004, 23(Suppl 1): S208-S219. DOI: 10.1016/j.neuroimage.2004.07.051.
[13]
FRIEDRICH P, FRAENZ C, SCHLÜTER C, et al. The Relationship Between Axon Density, Myelination, and Fractional Anisotropy in the Human Corpus Callosum[J]. Cereb Cortex, 2020, 14, 30(4): 2042-2056. DOI: 10.1093/cercor/bhz221.
[14]
LAZARI A, LIPP I. Can MRI measure myelin? Systematic review, qualitative assessment, and meta-analysis of studies validating microstructural imaging with myelin histology[J]. Neuroimage, 2021, 230: 117744. DOI: 10.1016/j.neuroimage.2021.117744.
[15]
LI L, LEI D, LI L J, et al. White Matter Abnormalities in Post-traumatic Stress Disorder Following a Specific Traumatic Event[J]. EBioMedicine, 2016, 4: 176-183. DOI: 10.1016/j.ebiom.2016.01.012.
[16]
SONG S K, SUN S W, RAMSBOTTOM M J, et al. Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water[J]. Neuroimage, 2002, 17(3): 1429-1436. DOI: 10.1006/nimg.2002.1267.
[17]
SONG S K, SUN S W, JU W K, et al. Diffusion tensor imaging detects and differentiates axon and myelin degeneration in mouse optic nerve after retinal ischemia[J]. Neuroimage, 2003, 20(3): 1714-1722. DOI: 10.1016/j.neuroimage.2003.07.005.
[18]
SONG S K, YOSHINO J, LE T Q, et al. Demyelination increases radial diffusivity in corpus callosum of mouse brain[J]. Neuroimage, 2005, 26(1): 132-140. DOI: 10.1016/j.neuroimage.2005.01.028.
[19]
HEMANTH KUMAR B S, MISHRA S K, et al. Demyelinating evidences in CMS rat model of depression: a DTI study at 7 T[J]. Neuroscience, 2014, 275: 12-21. DOI: 10.1016/j.neuroscience.2014.05.037.
[20]
MENG L H, CHEN Y, XU X, et al. The neurobiology of brain recovery from traumatic stress: A longitudinal DTI study[J]. J Affect Disord, 2018, 225: 577-584. DOI: 10.1016/j.jad.2017.08.075.
[21]
FURTADO M, KATZMAN M A. Neuroinflammatory pathways in anxiety, posttraumatic stress, and obsessive compulsive disorders[J]. Psychiatry Res, 2015, 229(1-2): 37-48. DOI: 10.1016/j.psychres.2015.05.036.
[22]
LEE D H, LEE J Y, HONG D Y, et al. Neuroinflammation in post-traumatic stress disorder[J]. Biomedicines, 2022, 10(5): 953. DOI: 10.3390/biomedicines10050953.
[23]
KORGAONKAR M S, GRIEVE S M, KOSLOW S H, et al. Loss of white matter integrity in major depressive disorder: evidence using tract-based spatial statistical analysis of diffusion tensor imaging[J]. Hum Brain Mapp, 2011, 32(12): 2161-2171. DOI: 10.1002/hbm.21178.
[24]
GUO W B, LIU F, CHEN J D, et al. Altered white matter integrity of forebrain in treatment-resistant depression: a diffusion tensor imaging study with tract-based spatial statistics[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2012, 38(2): 201-206. DOI: 10.1016/j.pnpbp.2012.03.012.
[25]
WANG Y, ZHAO T, XIE J, et al. The study of white matter micro-structures mediating onset age and the severity of depressive disorder based on DTI[J]. Chin J Magn Reson Imaging, 2021, 12(6): 1-4, 15. DOI: 10.12015/issn.1674-8034.2021.06.001.
[26]
CHEN L, LUI S, WU Q Z, et al. Impact of acute stress on human brain microstructure: An MR diffusion study of earthquake survivors[J]. Hum Brain Mapp, 2013, 34(2): 367-73. DOI: 10.1002/hbm.21438.
[27]
MORENO-LOPEZ Y, OLIVARES-MORENO R, CORDERO-ERAUSQUIN M, et al. Sensorimotor Integration by Corticospinal System[J]. Front Neuroanat, 2016, 10: 24. DOI: 10.3389/fnana.2016.00024.
[28]
JU Y M, OU W W, SU J Z, et al. White matter microstructural alterations in posttraumatic stress disorder: An ROI and whole-brain based meta-analysis[J]. J Affect Disord, 2020, 266: 655-670. DOI: 10.1016/j.jad.2020.01.047.
[29]
LIU Z W, KANG L J, ZHANG A X, et al. Injuries in Left Corticospinal Tracts, Forceps Major, and Left Superior Longitudinal Fasciculus (Temporal) as the Quality Indicators for Major Depressive Disorder[J]. Neural Plast, 2021, 2021: 2348072. DOI: 10.1155/2021/2348072.
[30]
SCHMAHMANN J D, PANDYA D N, WANG R, et al. Association fibre pathways of the brain: parallel observations from diffusion spectrum imaging and autoradiography[J]. Brain, 2007, 130(Pt 3): 630-653. DOI: 10.1093/brain/awl359.
[31]
JI L, JIANG W, LIU D Y, et al. Effect of SIRT1 on white matter neural network in adolescent patients with depression[J]. Front Psychiatry, 2022, 13: 966315. DOI: 10.3389/fpsyt.2022.966315.
[32]
WIINGAARD ULDALL S, LUNDELL H, BAARÉ W F C, et al. White matter diffusivity and its correlations to state measures of psychopathology in male refugees with posttraumatic stress disorder[J]. Neuroimage Clin, 2022, 33: 102929. DOI: 10.1016/j.nicl.2021.102929.
[33]
MENG L H, SHAN T, LI K M, et al. Long-term tract-specific white matter microstructural changes after acute stress[J]. Brain Imaging Behav, 2021, 15(4): 1868-1875. DOI: 10.1007/s11682-020-00380-w.
[34]
POLETTI S, MELLONI E, MAZZA E, et al. Gender-specific differences in white matter microstructure in healthy adults exposed to mild stress[J]. Stress, 2020, 23(1): 116-124. DOI: 10.1080/10253890.2019.1657823.
[35]
YEH P H, LIPPA S M, BRICKELL T A, et al. Longitudinal changes of white matter microstructure following traumatic brain injury in U.S. military service members[J/OL]. Brain Commun, 2022, 4(3): fcac132 [2023-03-27]. https://pubmed.ncbi.nlm.nih.gov/35702733/. DOI: 10.1093/braincomms/fcac132.
[36]
STENBERG J, SKANDSEN T, MOEN K G, et al. Diffusion tensor and kurtosis imaging findings the first year following mild traumatic brain injury[J]. J Neurotrauma, 2023, 40(5-6): 457-471. DOI: 10.1089/neu.2022.0206.
[37]
XU Y. Applications of FSL in the brain based on DTI[J]. Beijing Biomedical Engineering, 2016, 36(4): 420-426. DOI: 10.3969/j.issn.1002-3208.2017.04.016.
[38]
MENG L H, JIANG J, JIN C F, et al. Trauma-specific grey matter alterations in PTSD[J/OL]. Sci Rep, 2016, 6: 33748 [2022-10-12]. https://pubmed.ncbi.nlm.nih.gov/27651030/. DOI: 10.1038/srep33748.
[39]
BERMAN Z, ASSAF Y, TARRASCH R, et al. Macro-and microstructural gray matter alterations in sexually assaulted women[J]. J Affect Disord, 2020, 262: 196-204. DOI: 10.1016/j.jad.2019.10.024.

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