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• Clinical Article •
Application of magnetic resonance image compilation in the diagnosis of dermatomyositis/polymyositis and quantitative assessment of activity
WANG Yuqi  TIAN Zhaorong  ZHANG Liping  TIAN Bo  NI Yabo  WANG Zhijun 

WANG Y Q, TIAN Z R, ZHANG L P, et al. Application of magnetic resonance image compilation in the diagnosis of dermatomyositis/polymyositis and quantitative assessment of activity[J]. Chin J Magn Reson Imaging, 2023, 14(9): 92-96, 99. DOI:10.12015/issn.1674-8034.2023.09.016.


[Abstract] Objective To investigate the quantitative parameters of MR compilation on dermatomyositis (DM) / polymyositis (PM) the diagnostic value of activity, and the correlation between quantitative parameters and clinical indicators was analyzed.Materials and Methods The imaging data and clinical data of 68 patients with DM/PM confirmed by clinical and pathological methods in General Hospital of Ningxia Medical University were retrospectively collected, and the case group was divided into an active group (28 cases) and an inactive group (40 cases) according to the electromyogram and myositis disease activity tool. Another 24 normal volunteers matching the age, gender and body mass index (BMI) of the case group were also collected. SIGNA Architect 3.0 T MRI scanner was used to perform MAGiC sequence and conventional T1WI, T2WI and T2Flex sequence scanning on both thighs. The T2 and T1 values of the three thigh muscle groups were measured twice by two radiologists on the MAGiC sequence. One-way analysis of variance or Kruskal-Wallis H-test was used to compare the T2 and T1 values of different groups. Receiver operating characteristic (ROC) curves were plotted and the area under the curve (AUC) was calculated to analyze the diagnostic efficacy of T2 values for DM and its activity. Spearman correlation was used to analyze the correlation between DM/PM quantitative parameters and creatine kinase (CK) value.Results (1) The T2 values of anterolateral, medial and posterior muscles in DM/PM active group were higher than those in inactive group and control group (F values were 48.17, 94.60, 79.11, P＜0.05). The T1 value of the active group was higher than that of the inactive group and higher than that of the control group (F=16.13, P＜0.05). There was no significant difference between medial muscle group and posterior muscle group (P＞0.05). (2) The AUC value of T2 value of muscle groups in case group and control group was 0.939; the Youden index, sensitivity and specificity were 0.726, 81.5% and 91.0%, respectively. The AUC value of active and inactive muscle T2 values was 0.722, and the Youden index, sensitivity and specificity were 0.389, 57.1% and 81.8%, respectively. (3) The T2 value of the posterior muscle group was significantly positively correlated with CK (r=0.48, P＜0.05).Conclusions T2 value of MAGiC quantitative mapping technique can quantitatively analyze muscle involvement in DM/PM patients, which is highly correlated with clinical indicators of CK.
[Keywords] dermatomyositis/polymyositis；magnetic resonance imaging；image index；clinical index；activity

WANG Yuqi1   TIAN Zhaorong2   ZHANG Liping2   TIAN Bo2   NI Yabo1   WANG Zhijun2*  

1 Ningxia Medical University School of Clinical Medicine, Yinchuan 750001, China

2 Department of Radiology, General Hospital of Ningxia Medical University, Yinchuan 750001, China

Corresponding author: Wang ZJ, E-mail: wangzhijun2056@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Key Research and Development Plan of Ningxia Hui Autonomous Region (No. 2021BEG03033, 2023BEG03003).
Received  2023-04-06
Accepted  2023-08-04
DOI: 10.12015/issn.1674-8034.2023.09.016
WANG Y Q, TIAN Z R, ZHANG L P, et al. Application of magnetic resonance image compilation in the diagnosis of dermatomyositis/polymyositis and quantitative assessment of activity[J]. Chin J Magn Reson Imaging, 2023, 14(9): 92-96, 99. DOI:10.12015/issn.1674-8034.2023.09.016.

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