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Research progress on neuroimaging biomarkers of cognitive impairment in patients with type 2 diabetes
MEI Leilei  ZHANG Manman  YANG Hongkai  LUO Xiao  HE Yongsheng 

MEI L L, ZHANG M M, YANG H K, et al. Research progress on neuroimaging biomarkers of cognitive impairment in patients with type 2 diabetes[J]. Chin J Magn Reson Imaging, 2023, 14(9): 108-113. DOI:10.12015/issn.1674-8034.2023.09.020.


[Abstract] The onset of cognitive dysfunction associated with type 2 diabetes mellitus (T2DM) is insidious, and the specific mechanism remains unclear. Structural MRI can objectively measure brain volume and cortical morphological changes; diffusion weighted imaging can accurately track nerve fibers; quantitative susceptibility mapping can quantify the abnormal iron deposition in living tissues. Graph theory analysis can reflect the information processing efficiency of brain network; neurovascular coupling analysis can detect neurovascular injury; machine learning can build reliable diagnostic or predictive models. At present, the combination of multimodal MRI and advanced neuroimaging analysis theory has gradually become a powerful tool for clinical research on the mechanism of cognitive impairment in T2DM. The article reviewed the progress of multimodal MRI in the study of neuroimaging biomarkers of cognitive dysfunction in T2DM, in order to provide imaging evidence for revealing its neurophysiological mechanism and early diagnosis.
[Keywords] type 2 diabetes mellitus；cognitive impairment；neuroimaging biomarkers；magnetic resonance imaging；structural magnetic resonance imaging；functional magnetic resonance imaging；diffusion tensor imaging

MEI Leilei   ZHANG Manman   YANG Hongkai   LUO Xiao   HE Yongsheng*  

Department of Radiology, Maanshan People's Hospital, Ma'anshan 243000, China

Corresponding author: He YS, E-mail: heyongsheng881@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Science and Technology Project of Ma'anshan City (No. YL-2022-2).
Received  2023-03-08
Accepted  2023-07-27
DOI: 10.12015/issn.1674-8034.2023.09.020
MEI L L, ZHANG M M, YANG H K, et al. Research progress on neuroimaging biomarkers of cognitive impairment in patients with type 2 diabetes[J]. Chin J Magn Reson Imaging, 2023, 14(9): 108-113. DOI:10.12015/issn.1674-8034.2023.09.020.

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