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• Clinical Article •
Altered spatial and temporal concordance among intrinsic brain activity measures in Parkinson's disease patients with severe hyposmia
YANG Li  WANG Ming  REN Qinghui  DUAN Aowen  WEI Anhai 

Cite this article as: YANG L, WANG M, REN Q H, et al. Altered spatial and temporal concordance among intrinsic brain activity measures in Parkinson's disease patients with severe hyposmia[J]. Chin J Magn Reson Imaging, 2023, 14(10): 12-19. DOI:10.12015/issn.1674-8034.2023.10.003.


[Abstract] Objective This study investigated the spatial and temporal coupling alterations in the brain of Parkinson's patients with severe hyposmia (PD-SH) to understand the dynamic alterations of intrinsic brain activity in the PD-SH group.Materials and Methods The resting-state functional magnetic resonance imaging data acquired from 15 PD-SH, 15 Parkinson's disease patients with no/mild hyposmia (PD-N/MH), and 15 healthy controls (HC) were enrolled in this study. The volume-wise and voxel-wise concordance among four dynamic metrics was calculated. One-way analyses of variance and covariance analysis were used to compare the volume-wise and voxel-wise concordance among the PD-SH, PD-N/MH, and HC groups. The associations between concordance values and clinical/neuropsychological assessments were investigated as well.Results Compared with the PD-N/MH and HC, the PD-SH had lower dynamic volume concordance in the whole brain (P＜0.05). PD-SH showed increased voxel-wise concordance than PD-N/MH in left superior temporal gyrus, left cuneus, left postcentral gyrus and right precuneus (Gaussian random field correction, voxel level P＜0.005, cluster level P＜0.05). Compared with HC group, we found the decreased voxel-wise concordance in left inferior temporal gyrus, middle temporal gyrus, superior temporal gyrus and middle cingulum of PD-SH. Moreover, the decreased concordance in right middle cingulum was positively associated with the score of Odor Stick Identification Test for the Japanese in PD-SH (r=0.5251, P=0.0444).Conclusions There were some differences in the spatial and temporal concordance of intrinsic brain activity among the three groups. The analysis of concordance provided results and new insights into the neurophysiological mechanism of hyposmia in PD patients.
[Keywords] Parkinson's disease；olfactory dysfunction；resting-state functional magnetic resonance imaging；intrinsic brain activity；temporal dynamics analysis；magnetic resonance imaging

YANG Li1   WANG Ming2   REN Qinghui1   DUAN Aowen1*   WEI Anhai1  

1 Department of Medical Engineering, Daping Hospital of Army Military Medical University, Chongqing 400042, China

2 Department of Neurology, Daping Hospital of Army Military Medical University, Chongqing 400042, China

Corresponding author: DUAN A W, E-mail: duanaowen@foxmail.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Chongqing Doctoral "Fast-Service Channel" Research Project (No. CSTB2022BSXM-JCX0013); Chongqing Science and Technology Innovation Project of Social Undertaking and People's Livelihood Guarantee (No. cstc2017shmsA130074).
Received  2023-01-28
Accepted  2023-09-21
DOI: 10.12015/issn.1674-8034.2023.10.003
Cite this article as: YANG L, WANG M, REN Q H, et al. Altered spatial and temporal concordance among intrinsic brain activity measures in Parkinson's disease patients with severe hyposmia[J]. Chin J Magn Reson Imaging, 2023, 14(10): 12-19. DOI:10.12015/issn.1674-8034.2023.10.003.

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