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• Clinical Article •
Study on the synergistic effect of functional MRI on brain functional activity areas during limb linkage training in patients with Parkinson's disease
PALIDANMU·Wumaier   ALIMUJIANG·Abudukaiyoumu   WEIKELAMUJIANG·Zunong   AIJIEERGULI·Maihesumu   DAI Guozhao 

Cite this article as: PALIDANMU·W M E , ALIMUJIANG·A B D K Y M, WEIKELAMUJIANG·Z N, et al. Study on the synergistic effect of functional MRI on brain functional activity areas during limb linkage training in patients with Parkinson's disease[J]. Chin J Magn Reson Imaging, 2023, 14(10): 31-35, 41. DOI:10.12015/issn.1674-8034.2023.10.006.


[Abstract] Objective To explore he intervention mechanism of limb linkage training on patients with Parkinson's disease (PD) by using functional MRI (fMRI).Materials and Methods Fifty patients with Parkinson's disease who visited the First People's Hospital of Kashi area from April 2021 to February 2023 were collected as the case group, and 30 healthy volunteers matched with the baseline data were selected as the control group. The whole brain fMRI scanning of the two groups of subjects during limb linkage was performed.Results In the healthy control group, the brain activation areas mainly include right primary sensory motor cortex (SM1) (t=14.4829, P＜0.05), left primary sensory motor cortex (t=8.7640, P＜0.05), left auxiliary motor area (SMA) (t=8.4628, P＜0.05), right thalamus (t=9.3230, P＜0.05), right insular lobe (t=8.8615, P＜0.05), left superior temporal gyrus (t=9.0467, P＜0.05) and left inferior parietal lobule (t=10.8249, P＜0.05). In patients with Parkinson's disease, the brain activation areas mainly include right SM1 (t=10.0234, P＜0.05), left SMA (t=7.8221, P＜0.05), right insular lobe (t=6.3241, P＜0.05), left superior temporal gyrus (t=7.6571, P＜0.05) and left inferior parietal lobule (t=4.9862, P＜0.05). Compared with the healthy control group, the left SMA (t=6.011, P＜0.05), the right insular lobe (t=5.610, P＜0.05) and the left superior temporal gyrus (t=6.781, P＜0.05) were less activated in PD patients while the right SM1 (t=3.652, P＜0.05) was more activated.Conclusions Limb linkage training enhances the compensatory function of the primary motor function area in PD patients, which has theoretical guiding significance for the rehabilitation treatment of PD patients.
[Keywords] Parkinson's disease；functional magnetic resonance imaging；magnetic resonance imaging；limb linkage training；brain functional activation

PALIDANMU·Wumaier    ALIMUJIANG·Abudukaiyoumu    WEIKELAMUJIANG·Zunong    AIJIEERGULI·Maihesumu    DAI Guozhao*  

Department of Radiology, the First People's Hospital of Kashi Area, Kashi 844000, China

Corresponding author: DAI G Z, E-mail: daiguochaoct@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Natural Science Foundation of the Xinjiang Uygur Autonomous Region (No. 2021D01C022).
Received  2023-06-18
Accepted  2023-09-26
DOI: 10.12015/issn.1674-8034.2023.10.006
Cite this article as: PALIDANMU·W M E , ALIMUJIANG·A B D K Y M, WEIKELAMUJIANG·Z N, et al. Study on the synergistic effect of functional MRI on brain functional activity areas during limb linkage training in patients with Parkinson's disease[J]. Chin J Magn Reson Imaging, 2023, 14(10): 31-35, 41. DOI:10.12015/issn.1674-8034.2023.10.006.

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