Share：
Share this content in WeChat
X
[Chinese][PDF]2584
• Clinical Article •
Influencing factors of positive susceptibility vessel sign in patients with acute anterior circulation occlusive stroke
JIANG Han  LI Ziqiang  GAO Haiyan  BAI Yan  WEI Wei  WANG Meiyun 

Cite this article as: JIANG H, LI Z Q, GAO H Y, et al. Influencing factors of positive susceptibility vessel sign in patients with acute anterior circulation occlusive stroke[J]. Chin J Magn Reson Imaging, 2023, 14(10): 42-45, 52. DOI:10.12015/issn.1674-8034.2023.10.008.


[Abstract] Objective To investigate the influencing factors of susceptibility vessel sign (SVS) in acute anterior circulation occlusive stroke.Materials and Methods We retrospectively analyzed the data of 161 patients with acute stroke who underwent middle cerebral artery occlusion and MRI examination from July 16 2020 to June 24 2022, and all contained readable susceptibility-weighted imaging (SWI) information. The characteristics of the patients were compared according to the presence or absence of SVS. Univariate statistical analysis was performed, and then meaningful variables from the univariate statistical analysis were included in the multivariate statistical analysis.Results SVS+ was significantly correlated with age, cardiogenic stroke subtype and the combination of atrial fibrillation/flutter (P＜0.05). Multivariate analysis showed that combined atrial fibrillation/flutter was an independent risk factor for SVS+ (OR=4.296; 95% CI: 1.248-14.791, P=0.021). The difference between SVS+ and symptom onset -MRI time was not statistically significant.Conclusions SVS is still supported as a clinical marker for the diagnosis of the cause of acute ischemic stroke, even when symptom onset -MRI time is considered.
[Keywords] acute ischemic stroke；susceptibility vessel sign；magnetic resonance imaging；susceptibility-weighted imaging

JIANG Han1   LI Ziqiang2   GAO Haiyan3   BAI Yan3   WEI Wei3   WANG Meiyun3, 4*  

1 Department of Magnetic Resonance, Xinxiang Medical University & Henan Provincial People's Hospital, Zhengzhou 450003, China

2 Department of Magnetic Resonance, the First Affiliated Hospital of Xinxiang Medical University, Xinxiang 453100, China

3 Department of Medical imaging, Henan Provincial People's Hospital, Zhengzhou 450003, China

4 Laboratory of Brain Science and Brain-Like Intelligence Technology, Institute for Integrated Medical Science and Engineering, Henan Academy of Sciences, Zhengzhou 450003, China.

Corresponding author: WANG M Y, E-mail: mywang@zzu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS Medical Science and Technology Research Project of Henan Province (No. SBGJ202101002); Youth Project of Henan Natural Science Foundation (No. 222300420354).
Received  2023-04-21
Accepted  2023-09-21
DOI: 10.12015/issn.1674-8034.2023.10.008
Cite this article as: JIANG H, LI Z Q, GAO H Y, et al. Influencing factors of positive susceptibility vessel sign in patients with acute anterior circulation occlusive stroke[J]. Chin J Magn Reson Imaging, 2023, 14(10): 42-45, 52. DOI:10.12015/issn.1674-8034.2023.10.008.

[1]
CHEN H, DENG J P, YU J, et al. Analysis of the endovascular treatment of secondary occlusion and simple embolic occlusion in acute atherosclerotic stenosis of intracranial great arteries[J]. Chinese Journal of Clinical Neurosurgery, 2020, 25(2): 70-72. DOI: 10.13798/j.issn.1009-153X.2020.02.003.
[2]
SAKAMOTO Y, KIMURA K, SAKAI K. M1 susceptibility vessel sign and hyperdense middle cerebral artery sign in hyperacute stroke patients[J]. Eur Neurol, 2012, 68(2): 93-97. DOI: 10.1159/000338308.
[3]
CHOI M H, PARK G H, LEE J S, et al. Erythrocyte fraction within retrieved thrombi contributes to thrombolytic response in acute ischemic stroke[J]. Stroke, 2018, 49(3): 652-659. DOI: 10.1161/STROKEAHA.117.019138.
[4]
LIEBESKIND D S, SANOSSIAN N, YONG W H, et al. CT and MRI early vessel signs reflect clot composition in acute stroke[J]. Stroke, 2011, 42(5): 1237-1243. DOI: 10.1161/STROKEAHA.110.605576.
[5]
SILVAIN J, COLLET J P, NAGASWAMI C, et al. Composition of coronary thrombus in acute myocardial infarction[J]. J Am Coll Cardiol, 2011, 57(12): 1359-1367. DOI: 10.1016/j.jacc.2010.09.077.
[6]
KIM Y D, NAM H S, KIM S H, et al. Time-dependent thrombus resolution after tissue-type plasminogen activator in patients with stroke and mice[J]. Stroke, 2015, 46(7): 1877-1882. DOI: 10.1161/STROKEAHA.114.008247.
[7]
AOKI J, KIMURA K, SHIBAZAKI K, et al. DWI-ASPECTS as a predictor of dramatic recovery after intravenous recombinant tissue plasminogen activator administration in patients with middle cerebral artery occlusion[J]. Stroke, 2013, 44(2): 534-537. DOI: 10.1161/STROKEAHA.112.675470.
[8]
HALEFOGLU A M, YOUSEM D M. Susceptibility weighted imaging: Clinical applications and future directions[J]. World J Radiol, 2018, 10(4): 30-45. DOI: 10.4329/wjr.v10.i4.30.
[9]
SOIZE S, MANCEAU P F, GAUBERTI M, et al. Susceptibility vessel sign in relation with time from onset to magnetic resonance imaging[J]. Stroke, 2021, 52(5): 1839-1842. DOI: 10.1161/STROKEAHA.120.032198.
[10]
KANG D W, JEONG H G, KIM D Y, et al. Prediction of stroke subtype and recanalization using susceptibility vessel sign on susceptibility-weighted magnetic resonance imaging[J]. Stroke, 2017, 48(6): 1554-1559. DOI: 10.1161/STROKEAHA.116.016217.
[11]
LIU M, LI L, LI G. The different clinical value of susceptibility vessel sign in acute ischemic stroke patients under different interventional therapy: A systematic review and meta-analysis[J]. J Clin Neurosci, 2019, 62: 72-79. DOI: 10.1016/j.jocn.2019.01.002.
[12]
BOURCIER R, DERRAZ I, DELASALLE B, et al. Susceptibility Vessel Sign and Cardioembolic Etiology in the THRACE Trial[J]. Clin Neuroradiol, 2019, 29(4): 685-692. DOI: 10.1007/s00062-018-0699-8.
[13]
CHEN J, ZHANG Z, NIE X, et al. Predictive value of thrombus susceptibility for cardioembolic stroke by quantitative susceptibility mapping[J]. Quant Imaging Med Surg, 2022, 12(1): 550-557. DOI: 10.21037/qims-21-235.
[14]
RIOU-COMTE N, GORY B, SOUDANT M, et al. Clinical imaging factors of excellent outcome after thrombolysis in large-vessel stroke: a THRACE subgroup analysis[J]. Stroke Vasc Neurol, 2021, 6(4): 631-639. DOI: 10.1136/svn-2020-000852.
[15]
WONG G J, YOO B, LIEBESKIND D, et al. Frequency, determinants, and outcomes of emboli to distal and new territories related to mechanical thrombectomy for acute ischemic stroke[J]. Stroke, 2021, 52(7): 2241-2249. DOI: 10.1161/STROKEAHA.120.033377.
[16]
KIMURA K, IGUCHI Y, SHIBAZAKI K, et al. M1 susceptibility vessel sign on T2* as a strong predictor for no early recanalization after IV-t-PA in acute ischemic stroke[J]. Stroke, 2009, 40(9): 3130-3132. DOI: 10.1161/STROKEAHA.109.552588.
[17]
BOURCIER R, MAZIGHI M, LABREUCHE J, et al. Susceptibility vessel sign in the ASTER trial: higher recanalization rate and more favourable clinical outcome after first line stent retriever compared to contact aspiration[J]. J Stroke, 2018,20(2): 268-276. DOI: 10.5853/jos.2018.00192.
[18]
RITZENTHALER T, LACALM A, CHO T H, et al. Sequential MR assessment of the susceptibility vessel sign and arterial occlusion in acute stroke[J]. J Neuroimaging, 2016, 26(3): 355-359. DOI: 10.1111/jon.12312.
[19]
HALLER S, HAACKE E M, THURNHER M M, et al. Susceptibility-weighted imaging: technical essentials and clinical neurologic applications[J]. Radiology, 2021, 299(1): 3-26. DOI: 10.1148/radiol.2021203071.
[20]
ALLIBERT R, BILLON GRAND C, VUILLIER F, et al. Advantages of susceptibility-weighted magnetic resonance sequences in the visualization of intravascular thrombi in acute ischemic stroke[J]. Int J Stroke, 2014, 9(8): 980-984. DOI: 10.1111/ijs.12373.
[21]
WYCLIFFE N D, CHOE J, HOLSHOUSER B, et al. Reliability in detection of hemorrhage in acute stroke by a new three-dimensional gradient recalled echo susceptibility-weighted imaging technique compared to computed tomography: a retrospective study[J]. J Magn Reson Imaging, 2004, 20(3): 372-377. DOI: 10.1002/jmri.20130.
[22]
ADAMS H P, BENDIXEN B H, KAPPELLE L J, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment[J]. Stroke, 1993, 24(1): 35-41. DOI: 10.1161/01.str.24.1.35.
[23]
ROVIRA A, ORELLANA P, ALVAREZ-SABIN J, et al. Hyperacute ischemic stroke: middle cerebral artery susceptibility sign at echo-planar gradient-echo MR imaging[J]. Radiology, 2004, 232(2): 466-473. DOI: 10.1148/radiol.2322030273.
[24]
MARDER V J, CHUTE D J, STARKMAN S, et al. Analysis of thrombi retrieved from cerebral arteries of patients with acute ischemic stroke[J]. Stroke, 2006, 37(8): 2086-2093. DOI: 10.1161/01.STR.0000230307.03438.94.
[25]
KANAMOTO T, TATEISHI Y, YAMASHITA K, et al. Impact of width of susceptibility vessel sign on recanalization following endovascular therapy[J]. J Neurol Sci, 2023, 446:120583. DOI: 10.1016/j.jns.2023.120583.
[26]
Dillmann M, Bonnet L, Vuillier F, et al. Factors that influence susceptibility vessel sign in patients with acute stroke referred for mechanical thrombectomy[J]. Front Neurol, 2022, 13: 893060. DOI: 10.3389/fneur.2022.893060.
[27]
DE SOUZA J M, DOMINGUES R C, CRUZ L C, et al. Susceptibility-weighted imaging for the evaluation of patients with familial cerebral cavernous malformations: a comparison with t2-weighted fast spin-echo and gradient-echo sequences[J]. AJNR Am J Neuroradiol, 2008, 29(1): 154-158. DOI: 10.3174/ajnr.A0748.
[28]
HAYMAN L A, TABER K H, FORD J J, et al. Effect of clot formation and retraction on spin-echo MR images of blood: an in vitro study[J]. AJNR Am J Neuroradiol, 1989, 10(6): 1155-1158.
[29]
HORIE N, TATEISHI Y, MORIKAWA M, et al. Acute stroke with major intracranial vessel occlusion: Characteristics of cardioembolism and atherosclerosis-related in situ stenosis/occlusion[J]. J Clin Neurosci, 2016, 32: 24-29. DOI: 10.1016/j.jocn.2015.12.043.
[30]
DARCOURT J, GARCIA C, PHUONG D M, et al. Absence of susceptibility vessel sign is associated with aspiration-resistant fibrin/platelet-rich thrombi[J]. Int J Stroke, 2021, 16(8): 972-980. DOI: 10.1177/1747493020986626.
[31]
NIESTEN J M, VAN DER SCHAAF I C, VAN DAM L, et al. Histopathologic composition of cerebral thrombi of acute stroke patients is correlated with stroke subtype and thrombus attenuation[J/OL]. PLoS One, 2014, 9(2): e88882 [2023-03-14]. https://pubmed.ncbi.nlm.nih.gov/24523944/. DOI: 10.1371/journal.pone.0088882.

PREV 3D-ASL of arterial transit artifact and the intra-arterial high-intensity signal in the evaluation of short-term clinical outcomes in patients with acute ischemic stroke
NEXT The correlation between the number and location distribution of cerebral microbleeds and imaging of cerebral small vessel disease
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn