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• Clinical Article •
The correlation between the number and location distribution of cerebral microbleeds and imaging of cerebral small vessel disease
LI Jinze  ZHANG Luojin  FENG Jie  LI Xiaowan  SUN Jingshuang  YANG Benqiang  DUAN Yang 

Cite this article as: LI J Z, ZHANG L J, FENG J, et al. The correlation between the number and location distribution of cerebral microbleeds and imaging of cerebral small vessel disease[J]. Chin J Magn Reson Imaging, 2023, 14(10): 46-52. DOI:10.12015/issn.1674-8034.2023.10.009.


[Abstract] Objective To evaluate the number and location distribution of cerebral microbleeds (CMBs) based on susceptibility weighted imaging (SWI), and analyze the correlation with the severity of cerebral small vessel disease (CSVD).Materials and Methods Three hundred and ninety four patients who diagnosed with CSVD by clinical and imaging features were enrolled in this study. Evaluating the imaging markers of CSVD, including lacunar lacunae (LI), white matter hyperintensities (WMH), CMBs, recent small subcortical infarct (RSSI), perivascular spaces (PVS) and cerebral atrophy. The total CSVD score was calculated to evaluate the severity of CSVD. The Microhemorrhage Anatomical Rating Scale (MARS) were used to evaluate the distribution and severity of CMBs. The correlation between the severity and location distribution of CMBs and the imaging characteristics of CSVD was analyzed.Results There were statistical differences in the severity of CMBs in terms of age, WMH, brain atrophy and the total CSVD score (P=0.005; P＜0.001; P=0.005; P＜0.001). After adjusting for age, the severity of CMBs was correlated with the total CSVD score and WMH (r=0.441, P＜0.001; r=0.380, P＜0.001). The location distribution of CMBs was correlated with WMH. The modified Fazekas scores of mixed CMBs group was significantly higher than that of simple lobar type, simple deep type and simple subtentorial type (P=0.011; P=0.034; P=0.023).Conclusions The severity and distribution of CMBs are related to WMH and the severity of CMBs is related to the total CSVD score.
[Keywords] cerebral microbleeds；cerebral small vessel disease；susceptibility-weighted imaging；magnetic resonance imaging；Microbleed Anatomical Rating Scale

LI Jinze1   ZHANG Luojin2   FENG Jie3   LI Xiaowan3   SUN Jingshuang2   YANG Benqiang4   DUAN Yang4*  

1 Jinzhou Medical University General Hospital of Northern Theater Command Postgraduate Training Base, Shenyang 110016, China

2 Dalian Medical University General Hospital of Northern Theater Command Postgraduate Training Base, Shenyang 110016, China

3 China Medical University General Hospital of Northern Theater Command Postgraduate Training Base, Shenyang 110016, China

4 Department of Radiology, General Hospital of Northern Theater Command, Shenyang 110016, China

Corresponding author: DUAN Y, E-mail: duanyang100@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS 2022 Science and Technology Project of Liaoning Province (No. 2022JH2/101500024); 2020 Science and Technology Project of Shenyang (No. 20-205-4-044).
Received  2023-05-16
Accepted  2023-09-26
DOI: 10.12015/issn.1674-8034.2023.10.009
Cite this article as: LI J Z, ZHANG L J, FENG J, et al. The correlation between the number and location distribution of cerebral microbleeds and imaging of cerebral small vessel disease[J]. Chin J Magn Reson Imaging, 2023, 14(10): 46-52. DOI:10.12015/issn.1674-8034.2023.10.009.

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