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• Clinical Article •
Application value of 3.0 T MAGIC relaxation time quantitative technique in neonates with acute bilirubin encephalopathy
LI Yan  ZHANG Xiaoyu  LIU Lingling  LI Peng  LIU Shili  CHEN Zhiqiang  Zhang Shening  QIU Yinping  YANG Ping 

Cite this article as: LI Y, ZHANG X Y, LIU L L, et al. Application value of 3.0 T MAGIC relaxation time quantitative technique in neonates with acute bilirubin encephalopathy[J]. Chin J Magn Reson Imaging, 2023, 14(10): 65-70, 97. DOI:10.12015/issn.1674-8034.2023.10.012.


[Abstract] Objective To investigate the application value of MAGIC relaxation time quantitative technique in the evaluation of acute bilirubin encephalopathy (ABE).Materials and Methods Thirty-two children with confirmed ABE (ABE group) admitted to the PICU of Ningxia Medical University for jaundice from October 2020 to June 2022, 71 children with hyperbilirubinemia (hyperbilirubinemia group), and 44 normal-term children (control group) as the study subjects. All the included subjects completed cranial MAGIC examination in our hospital within 10 days after birth, and measured the relaxation value T1, T2 andproton density (PD) values in 6 areas of interest (ROI), including bilateral glous pallidus, putamen, ventrolateral thalamic nucleus, posterior limb of internal capsule, anterior limb of internal capsule, pedunculus cerebri. The values of T1, T2 and PD among all groups were compared by one-way variance analysis; the area under the curve (AUC), optimal critical value, sensitivity, specificity and Yoden index of ABE were analyzed by receiver operating characteristic (ROC) curve; Pearson correlation was used to analyze the correlation between T1, T2, PD and total serum bilirubin (TSB) in each area of interest.Results The values of T1 and T2 in the globus pallidus were statistically significant among the three groups (P＜0.05), which were the lowest in ABE, followed by the high bile group, and the highest in the control group. The T1 and T2 values of the posterior limb of the internal capsule and the T1 values of the pedunculus cerebral were statistically different among the three groups (P＜0.05), with the highest value in the ABE group, followed by the high bile group, and the lowest in the control group. In T1, the pallidum AUC (0.977) had the highest sensitivity (95.3%), specificity (92.0%), the posterior limb and the cerebral foot; in T2, the pallidum AUC (0.880), the posterior capsule AUC (0.857), the slightly higher pallidum specificity (82.1%), and the internal capsule (79.1%). T1 values of the globus pallidus were negatively correlated with TSB (r=-0.541, P＜0.05), and T1 values of the posterior limb of the internal capsule and the peduncle were positively correlated with TSB (r=0.503, 0.384, all P＜0.05).Conclusions Relaxation time quantitative technique of MAGIC has high clinical value in the diagnosis of neonatal ABE. The measurement of T1 and T2 values of the globus pallidus, posterior limb of the internal capsule and the T1 values of the cerebral pedicle can provide objective and quantitative imaging reference basis for the early clinical diagnosis of neonatal ABE.
[Keywords] newborn；hyperbilirubinemia；bilirubin encephalopathy；integrated magnetic resonance imaging；magnetic resonance imaging；globus pallidus

LI Yan1   ZHANG Xiaoyu1   LIU Lingling1   LI Peng1   LIU Shili1   CHEN Zhiqiang1, 2*   Zhang Shening1   QIU Yinping3   YANG Ping3  

1 Department of Radiology, General Hospital of Ningxia Medical University, Yinchuan 750004, China

2 Department of Radiology, the First Affiliated Hospital of Hainan Medical College, Haikou 570100, China

3 Department of Neonatology, General Hospital of Ningxia Medical University, Yinchuan 750004, China

Corresponding author: CHEN Z Q, E-mail: zhiqiang_chen99@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Key Research and Development Program of the Ningxia Hui Autonomous Region (No. 2019BEG03033);Natural Science Foundation of the Ningxia Hui Autonomous Region (No. 2022AAC03472); University-level Project of Ningxia Medical University (No. XM2021071).
Received  2023-04-17
Accepted  2023-09-28
DOI: 10.12015/issn.1674-8034.2023.10.012
Cite this article as: LI Y, ZHANG X Y, LIU L L, et al. Application value of 3.0 T MAGIC relaxation time quantitative technique in neonates with acute bilirubin encephalopathy[J]. Chin J Magn Reson Imaging, 2023, 14(10): 65-70, 97. DOI:10.12015/issn.1674-8034.2023.10.012.

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