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Research progress of functional MRI-based neurovascular coupling in central nervous system diseases
RAN Haifeng  ZHANG Tijiang 

Cite this article as: RAN H F, ZHANG T J. Research progress of functional MRI-based neurovascular coupling in central nervous system diseases[J]. Chin J Magn Reson Imaging, 2023, 14(10): 132-136. DOI:10.12015/issn.1674-8034.2023.10.023.


[Abstract] Central nervous system diseases are a class of disorders that often lead to irreversible damage and have poor prognosis. Early intervention can significantly enhance the prognosis for these diseases. Neurovascular coupling (NVC) is a crucial neural mechanism responsible for maintaining normal physiological functions of the human brain. NVC decoupling may be an underlying pathophysiological mechanism in various central nervous system diseases. Functional MRI (fMRI) is a non-invasive imaging technique widely recognized for its effectiveness in studying the functional organization of the human brain. The utilization of fMRI techniques to non-invasively investigate NVC decoupling in diseased states holds significant implications for a better understanding the pathophysiological mechanisms, early diagnosis, and early intervention of central nervous system diseases. This article review the literature of fMRI-based NVC researches within central nervous system diseases, in order to find out the potential neuroimaging biomarkers for such disorders and provide an objective foundation for early disease diagnosis, treatment, and prognosis assessment, thereby offering a novel perspective for future research endeavors in the field of central nervous system diseases.
[Keywords] central nervous system diseases；neurovascular unit；neurovascular coupling；functional magnetic resonance imaging；magnetic resonance imaging

RAN Haifeng   ZHANG Tijiang*  

Department of Radiology, the Affiliated Hospital of Zunyi Medical University, Zunyi 563000, China

Corresponding author: ZHANG T J, E-mail: tijzhang@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 82171919, 81960312); Intelligent Medical Imaging Engineering Research Center Project of Higher Education in Guizhou Province (No. Qian Jiao Ji [2023] 038).
Received  2023-04-13
Accepted  2023-09-11
DOI: 10.12015/issn.1674-8034.2023.10.023
Cite this article as: RAN H F, ZHANG T J. Research progress of functional MRI-based neurovascular coupling in central nervous system diseases[J]. Chin J Magn Reson Imaging, 2023, 14(10): 132-136. DOI:10.12015/issn.1674-8034.2023.10.023.

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